Interleukin-1 alpha induced release of interleukin-8 by human bronchial epithelial cells in vitro University of Antwerp KU Leuven
Survival after lung transplantation is hampered by chronic lung allograft dysfunction (CLAD). Persistently elevated BAL-neutrophilia is observed in some patients despite treatment with azithromycin, which may be induced by IL-1 alpha. Our aim is to establish an in vitro model, assess mechanistic pathways and test different therapeutic strategies of IL-1 alpha-induced release of IL-8 by human bronchial epithelial cells. Bronchial epithelial cells ...