Projects
Clinical prediction models in intensive care. KU Leuven
Exposure of premature neonates to bisphenol A and phthalates at the intensive care unit: accumulation in hair and long-term neurodevelopmentel and pulmonary toxicity. University of Antwerp
Persisting muscle weakness after prolonged intensive care stay: incidence, risk factors, pathomysiology and contribution to long-term physical disabilities. KU Leuven
As ICU survival has markedly increased during the past decades, devastating sequellae of critical illness are becoming clear. ICU survivors manifest long-term physical disability and decreased quality of life. Several factors may contribute to this ‘legacy’ of critical illness. One of the main suggested contributors is delayed recovery from neuromuscular weakness acquired in the ICU (ICUAW). In this project we focus on the gap in knowledge on ...
Exposure to plasticizers leaching from plastic medical devices in Neonatal Intensive Care and impact on the long-term neurocognitive and pulmonary development. University of Antwerp
Intensive care extended beyond the “adaptive” time window: from impact on the adrenocortical ‘fight or flight’ response towards a possible new treatment KU Leuven
The hormone cortisol is an essential component of the ‘fight or flight’ response to illness and trauma. Normally, when the brain senses a stressful event, the hypothalamic-pituitary-adrenal axis is activated, and the hypothalamus releases corticotropin-releasing hormone (CRH), which stimulates the anterior pituitary to secrete adrenocorticotropic hormone (ACTH), which drives cortisol synthesis and secretion from the adrenal cortex. Cortisol ...
''Stealing effect'' during weaning from mechanical ventilation: The role of blood flow competition between respiratory muscles and cerebral cortex on weaning outcomes in the medical intensive care unit. KU Leuven
Weaning covers the entire process of liberating the patient from mechanical ventilation support and the endotracheal tube. For the majority of mechanically-ventilated patients weaning can be successfully accomplished quickly and easily, however this is not the case for 15-30% of ventilated patients. Prolonged mechanical ventilation secondary to weaning failure sacrifices a significant amount of intensive care resources, thus increasing the ...
Chitinase (3-like) proteins as novel acute kidney injury biomarkers in intensive care patients Ghent University
Up to 2/3 of human intensive care patients develop acute kidney injury (AKI), which is independently associated with hospital-mortality. In canine patients, AKI is also accociated with a high mortality. Urinary chitinase (3-like) proteins are promising AKI biomarkers in our mouse sepsis model. Their genesis, function and processing in preclinical, as well as their diagnostic value in clinical conditions, are investigated.
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Flemish interuniversity intensive care database project Ghent University
The aim of this project is to create an interuniversity database containing high-quality and complexly interrelated data from all patients admitted to the intensive care units (ICU) of the university hospitals participating. Each of the 3 ICUs participating already has a fully operational commercial PDMS. Integrating these existing databases into one unique database may at first seem simple but is, in fact, a complex project. The added-value ...