Projects
Implementation of a longitudinal multi-omics prediction model for response to immune checkpoint inhibition Ghent University
Treatment with immune checkpoint inhibitors (ICIs) is becoming the systemic “standard of care” for an increasing number of cancer patients. The purpose of this treatment is boosting the host immune system to destroy the cancer cells but, unfortunately, it is very costly and only a fraction of patients (20-40%) show response. Accurate and rapid prediction of response could avoid undergoing this costly treatment unnecessarily while enabling ...
Stabilization of atherosclerotic plaques via inhibition of intraplaque neovascularization. University of Antwerp
Cell wall-degrading enzyme inhibition and health beneficial effects of phenolic compounds by solid-state fermentation from Brassica waste Ghent University
Production of Brassica leads to a high amount of by-products, rich in phenolic compounds. In this study, extracts rich in phenolic compounds will be prepared, after treating the by-products using specific micro-organisms, particularly fungi. These extracts will be characterized based on the phenolic compounds present by UPLC-MS. Also the extracts will be tested on their bio-activity potential, i.e. ACE-inhibitory and anti-obesity activity, ...
Local Rho kinase inhibition in murine colitis: mode of action Ghent University
Rho kinase (ROCK) inhibition is a possible new target in the treatment of inflammatory bowel diseases (IBD). It is a pleiotropic kinase that plays an important role in inflammation and gut homeostasis and it is overproduced in IBD. This researchproject investigates the effects and molecular mechanisms of locally administrated ROCK inhibitors in murine colitis.
Development of innovative approaches based on quorum sensing inhibition to prevent and treat medical device-related infections Ghent University
Biofilm-associated microorganisms are resistant to antibiotics, causing problems for the treatment of biofilm-related infections. Bacterial cell-cell communication (quorum sensing, QS) may contribute to biofilm resistance. The goal is to develop biomaterials loaded with QS inhibitors and to evaluate their effect on microbial adhesion and/or antibiotic susceptibility. Besides this, combination therapy will be evaluated in chronic wound and ...
Inhibition of lung inflammation in pneumonia induced by micro-organisms KU Leuven
Genetic rescue of behavioral alterations in the Nlgn3 R451C mutation mouse model for autism spectrum disorder: Targeting brain excitation/ inhibition imbalance KU Leuven
Effects of early-life environmental factors on response inhibition and impulsive aggression Ghent University
Impulsive aggression (IA) refers to a behavioural response that inflicts physical or emotional damage to the self, other individuals, or objects. Control of IA is often attributed to response inhibition (RI), which refers to the ability to suppress inappropriate actions. RI deficits have been linked with various psychopathological disorders and behavioral problems, including IA. Furthermore, IA is influenced by early-life (pre- and ...