Projects
Lineage plasticity of regulatory T cells in high-grade glioma as a tool to improve immunotherapy. KU Leuven
Characterisation of allergen-induced T cells from healthy individuals KU Leuven
1/ Investigation of new genes causing disease in children diagnosed with autoimmune/autoinflammation disorders. 2/ Systems immunology to assess adverse side effect after immunotherapy. KU Leuven
The role of the C3H1 zinc finger protein Roquin1 in inflammation, from a genetic survey in hyperinflammatory disorders to therapeutic applicability. Ghent University
Hyperinflammatory diseases are rare but often severely debilitating and life-threatening diseases. Although inborn errors of the immune system are at the basis of hyperinflammatory diseases, our knowledge of the underlying genetic defects remains incomplete. This strongly impedes early diagnosis and restricts patients from obtaining optimal healthcare. Furthermore, failure to
understand the molecular mechanisms driving these disorders ...
Gene discovery and development of targeted treatment in severe early-onset autoinflammatory diseases. KU Leuven
The field of IEI is evolving at a rapid pace with the introduction of next generation sequencing (NGS) in 2010, close collaboration between clinicians and researchers, availability of new tools and model organisms and identification of novel clinical phenotypes. The historical view on IEI limited to a predisposition to infection has been abandoned for a comprehensive view on disease with classification based on the primary immune subset ...
In-depth investigation of autoinflammatory disorders KU Leuven
Monogenic inherited disorders can cause a variety of disease phenotypes and as a whole pose a serious burden on the healthy system due to the high number of patients affected. In order to administer efficient treatment and provide informed counselling support, the genetic basis of the disorder needs to be identified. While the number of genes causing hereditary disorders is constantly rising, many patients still remain without a genetic ...