Projects
Regulation of the immune response to encapsulated Streptococcus pneumoniae. KU Leuven
The general objective of the proposed research is to better understand the regulation of the human immune response to S. pneumoniae. The specific aims are:
- To characterize the B cell subset involved in the antibody response to S. pneumoniae in general and (pneumococcal) polysaccharides in particular.
- To unravel the role of T cells and co-stimulatory interactions in the immune response to S. ...
The role of costimulatory interactions, antigen presenting cells and natural killer cells in the human immune response to encapsulated S. pneumoniae. KU Leuven
Autoinflammatory disorders: from new genetic variant identification to in-depth immunophenotyping of large patient cohorts KU Leuven
Human Inborn Errors of Immunity are a specific disease entity caused by monogenic germline variants that lead to severe immune disorders. Many patients suffering from systemic immunological disorders at present still lack a genetic diagnosis or molecular understanding of their disease. Identification of the causing gene would facilitate medical treatment in those patients. The aim of this PhD project is to identify new genetic variants that ...
In the moonlight of GTF3A: a new way to see innate antiviral signaling? Ghent University
Herpes viruses are omnipresent in the human population and cause a range of benign but unpleasant diseases. However, in a small percentage of people, infections with herpes viruses become recurrent or invasive resulting in increased morbidity and mortality. The quintessential example is herpes encephalitis (HSE) that causes neurological sequela in most patients and lethality up to 25% even with appropriate antiviral treatment. The immune ...
Follow up of Newborns's Immune development in relation to Allergic outcome; FONIA birth cohort KU Leuven
Mechanisms underlying airway sensitisation and tolerance towards major allergens of Dermatophagoides mites. KU Leuven
Comprehensive Imaging of the Respiratory system for Construing Early lung disease in Cystic Fibrosis (the CIRCE-CF study). KU Leuven
In Europe, CF is the most common life shortening inherited disorder. Median survival is 37 years. Most patients die from lung disease (CFLD).
Much can be gained from prevention or better treatment of early CFLD. Since CF newborn screening is available in many European countries, this task becomes even more important. CFLD is thought to affect the small airways early in life. So far no one has managed to directly show this as the small ...