Projects

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Towards an Atlas of Human Genomic Imprinting University of Antwerp

Geert Vandeweyer
Cognitive Genetics (COGNET)
Imprinting refers to mono-allellic expression of genes. It is involved in developmental disorders and in tumor development. As the extend of imprinting in human is currently unknown, we will use RNA-sequencing to generate a comprehensive atlas of imprinted genes and parental origins of the expressed alleles. This will be of great value in the interpretation of genome wide data, from techniques such as microarray and whole exome sequencing.

Gnotobiotic Artemia brine shrimp as a model for studying the transcriptional, translational and epigenetic mechanisms responsible for immune 'imprinting' against infectious diseases in invertebrates Ghent University

Daisy Vanrompay
Department of Animal Sciences and Aquatic Ecology, Department of Animal production

Invertebrates, including shrimps, rely on their innate immunity to fight against pathogens. Innate immunity lacks the ability to show high degree of specificity and long-lasting memory. However, few reports claimed that invertebrates show some form of immunological specificity and memory similar to that of adaptive immunity in vertebrates. Using the gnotobiotic brine shrimp Artemia as model organism, this project aims to unambiguously prove ...

Innate imprinting of resident alveolar macrophages by allergic airway inflammation: mechanism and consequences for asthma exacerbation Ghent University

Hamida Hammad
Department of Internal medicine, Department of Biomedical molecular biology

In a mouse model of asthma, resident alveolar macrophages showed an increased inflammatory reactivity upon post-infection of the asthmatic lung. This project aims to elucidate the mechanism underlying the altered macrophage innate functionality and hereby to enable interference with asthma exacerbation.



Analytical separations of complex samples using novel affinity matrices based on molecularly imprinted polymers Hasselt University

Thomas CLEIJ
Organic and Bio-polymer Chemistry
Molecularly Imprinted Polymers (MIPs) are synthetic receptors, which can bind target molecules with a high selectivity and affinity. The general concept of molecular imprinting is based on a polymerization of functional monomers and cross-linkers, surrounding a target molecule. The aim of this project is the development of novel MIPs and their direct integration into analytical separation methods. The miniaturization, which can be achieved in ...

Design and development of molecular imprinted polymers with high affinity to the template based on one building block. Hasselt University

Dirk VANDERZANDE
Organic and Bio-polymer Chemistry
This research focuses specifically on developing new synthesis routes to synthesize Molecular Imprinted Polymers (MIPs). MIPs are synthetic polymeric analogues of anti-bodies, ie molecules that can serve as a receptor for other molecules. Therefore, they are a possible component of a sensor system for biomolecules. By using a "template molecule" in the presence of all components to synthesize the MIP, a nano-porous matrix with an affinity for ...

Molecularly imprinted polymers as a clean-up technique for T-2 toxin, HT-2 toxin and patulin in complex food matrices Ghent University

Sarah De Saeger
Department of Bio-analysis

The general procedures to trace food contaminants consists of 3 steps: extraction, clean-up and a detection/quantification step. Regarding the first steps immunoaffinity columns exhibit excellent selectivity, but this technique has many disadvantages (expensive, not reusable, U+2026). The purpose of this project is to develop molecularly imprinted polymers applicable for T-2, HT-2 and patulin as an alternative for immunoaffinity columns.

Towards disposable diagnostic sensors for small molecules based on Molecularly Imprinted Polymers using the Heat Transfer Method Hasselt University

Ronald THOELEN
Engineering Materials and Applications, Organic and Bio-polymer Chemistry
Label-free sensors based on electrical, mechanical and optical transduction methods have applications in numerous areas of society, ranging from healthcare to environmental monitoring. Despite the need, translation of biosensors from research laboratories to actual applications has remained limited to few examples. The past decade an interesting approach toward the use of synthetic receptors has been represented by the use of molecularly ...

Moleculary Imprinted Polymers for Waste Water Treatment Hasselt University

Tanja JUNKERS
Organic and Bio-polymer Chemistry
The IOF-project WasteWaterMIP aims to develop methods to remove API contamination (active pharmaceutical ingredients) in waste water streams based on MIP technology. The projects aims to generate IP in this domain, and in a later stage the creation of a spin-off is a possibility. This project is a collaboration between the imo-imomec institute of UHasselt and a company. Several pharmaceutical companies have already shown strong interest as a ...

Smart Cellular Scaffolds. KU Leuven

Patrick Wagner
Soft Matter and Biophysics
In vivo, cells are supported by an extracellular matrix that specifically dictates the fate of resident cells through chemical, topographical or mechanical stimuli. One of the current challenges in materials and biomedical sciences is to mimic this natural environment, and to make cells feel more at home so that they can heal or replace a damaged tissue or interface with an electronic sensor chip. One potentially successful strategy to address ...