Publications
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Cellular immunity in patients with genital human papilloma virus (HPV) before and after treatment Institute of Tropical Medicine
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity University of Antwerp Institute of Tropical Medicine Ghent University KU Leuven
Self-amplifying RNA vaccines may induce equivalent or more potent immune responses at lower doses compared to non -repli-cating mRNA vaccines via amplified antigen expression. In this paper, we demonstrate that 1mg of an LNP-formulated dual -antigen self-amplifying RNA vaccine (ZIP1642), encoding both the S-RBD and N antigen, elicits considerably higher neutral-izing antibody titers against Wuhan-like Beta B.1.351 and Delta B.1.617.2 SARS-CoV-2 ...
Modulation of cellular and molecular components of innate immunity by a polysaccharide derivative as a strategy against virus infections KU Leuven
Despite numerous therapeutic achievements, infectious diseases, such as viral infections, remain a continuous hazard to human health, in part due to emergence or re-emergence of new and hazardous viruses or the lack of appropriate vaccines or prophylactic or post-exposure therapies. Successful elimination of infectious viruses highly depends on the dynamic interplay between leukocytes and proteins of the fast-responding broad-spectrum innate and ...
Evaluation of Cellular Immunity to Mumps in Immunized Individuals with and without Circulating Antibodies up to 16 Years after Last Vaccination KU Leuven Ghent University University of Antwerp
In this observational study mumps-specific in vitro lymphoproliferation was measured in 24 subjects with low and 24 subjects with high antibody titers who received the last vaccine dose up to 16 years before. Overall, a significant lymphoproliferative response was found in 32 subjects (66.7%), namely in 54.2% of those with low and in 79.2% of the subjects with high antibody titers. The mean stimulation index (SI) in those with low and high ...
High Incidence of SARS-CoV-2 Variant of Concern Breakthrough Infections Despite Residual Humoral and Cellular Immunity Induced by BNT162b2 Vaccination in Healthcare Workers: A Long-Term Follow-Up Study in Belgium KU Leuven
To mitigate the massive COVID-19 burden caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several vaccination campaigns were initiated. We performed a single-center observational trial to monitor the mid- (3 months) and long-term (10 months) adaptive immune response and to document breakthrough infections (BTI) in healthcare workers (n = 84) upon BNT162b2 vaccination in a real-world setting. Firstly, serology was determined ...
Cellular networks controlling Th2 polarization in allergy and immunity Ghent University
In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of allergy. A picture is emerging in which mucosal epithelial cells instruct dendritic cells to promote Th2 responses in the absence of IL-12 (interleukin 12) production and provide instruction through ...
Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits Ghent University KU Leuven
Anti-aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity KU Leuven
Both interferon-gamma-producing type 1 T helper (Th1)- and interleukin-17 (IL-17)-producing Th17 cells have been proposed to be involved in anti-fungal host defence. Although invasive aspergillosis is one of the most severe human fungal infections, little is known regarding the relative importance of the Th1 versus Th17 cellular immune pathways for the human anti-Aspergillus host defence. Using human peripheral blood mononuclear cells and a ...
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment Vrije Universiteit Brussel
OBJECTIVES: To characterize the host response to dendritic cell-based immunotherapy and subsequent combined antiretroviral therapy (cART) interruption in HIV-1-infected individuals at the plasma protein level.
DESIGN: An autologous dendritic cell (DC) therapeutic vaccine was administered to HIV-infected individuals, stable on cART. The effect of vaccination was evaluated at the plasma protein level during the period preceding cART ...