Projects
Exploring the potential and underlying mechanisms of therapeutic activation of p53 in combination with immunotherapy to stimulate an innate immune response against non-small cell lung cancer. University of Antwerp
The allogeneic immune response in chronic rejection after lung transplantation – A study of human and mouse KU Leuven
Lung transplantation is a well-accepted treatment option for patients with end-stage lung disease. The outcome of lung transplantation is hampered by chronic rejection, which has a 50% prevalence 5years after transplantation. Due to chronic rejection the mortality rate in lung transplantation (50% after 5 years) is much higher compared to other solid organ transplantations (<30% after 5 years). Until recently, the treatment of chronic ...
Modulating the epigenome using histone deacetylase inhibitors: inducing a type 2 immune response switch to promote recovery after trauma to the spinal cord Hasselt University
The influence of cigarette smoke on the innate and adaptive intestinal immune response and on the pathogenesis of Crohn's disease. Ghent University
Peyer's patches play an important role in the development of the normal mucosal immune response furthermore this is the region where first manifestations of Crohn's desease (CD) occur. Smoking has a detrimental role in CD pathogenesis we want to investigate the influence of cigarette smoke on mucosal immunity and receal how this can lead to the development of CD
Exploring the potential and underlying mechanisms of therapeutic activation of p53 in combination with immunotherapy to stimulate an innate immune response against non-small cell lung cancer. University of Antwerp
Role of the nuclear peroxisome proliferator-activated receptors (PPAR) in the intestinal immune response against the protozoan parasites Giardia duodenalis and Giardia muris Ghent University
Peroxisome Proliferator-Activated Receptors (PPAR) are ligand-activated transcription factors that control both lipid and glucose homeostasis and the regulation of immune responses. Recent observations suggest a role for the PPARs in the host response following infections with the protozoan parasites Giardia duodenalis. The aim of this project is to unravel the role and regulation of the PPARs following infection.
Assessment of pneumococcal immune response in infants whose mothers received Tdap vaccination during pregnancy. University of Antwerp
Research on the containment of antibiotic resistance and the immune response of prophylactic and therapeutic vaccines. University of Antwerp
Unraveling the role of IL-17A in the intestinal immune response against the protozoan parasites Giardia duodenalis and Giardia muris. Ghent University
The aim of this project is to fill a gap in the current knowledge on how IL-17A affects the mucosal immune response against the unicellular parasites Giardia duodenalis en Giardia muris