Coevolution of epithelium and immune response in colorectal cancer: comprehensive longitudinal analysis and manipulation of crosstalk leading to exhausted responses in dedicated mouse models. KU Leuven
Overall MSS colorectal cancer (CRC) is considered a cold tumor, nonresponsive
to immunotherapy, in contrast to MSI CRC. We observe all MSS
are dysfunctional at the level of T cell responses, but with heterogeneous
mechanisms with some having cytotoxic CD8 T cells stuck in stroma,
whereas in others T cells are in tolerogenic/pro-tumorigenic states as Treg
and Th17, or some are entirely cold. Our extensively mapped ...