Mutation profiles and targeted treatment options for mismatch repair deficient tumors KU Leuven
Defects in DNA repair mechanisms contribute to tumor development in a significant number of human cancers. For instance, up to 20% of colorectal and endometrial tumors are characterized by deficiency of the mismatch repair (MMR) genes (MLH1, MSH2 and MSH6). In the current project, we will apply whole-genome sequencing to tumors characterized by MMR-deficiency and their matched normal DNA samples and will assess whether specific patterns of ...