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Effect of nutrient limitation (phosphorus limitation) on the floristic diversity in an undisturbed wetland. University of Antwerp

Several factors determine the realized species pool in a wet meadow system. Hydrology partly influences the plant-available nutrients, directly by controlling the supply through ground and flooding water,¿ and indirectly by the groundwater level, controlling the soil moisture content and thus the redox potentiaal which determines the available nitrogen (N) and phosphorus (P) forms.The amount of available nutrients is also determined by the ...

A Functional-Cognitive Perspective on Social Modulation of Imitation in Individuals With and Without Autism Spectrum Disorder Ghent University

Roeljan Wiersema

Department of Experimental clinical and health psychology

Imitation plays a central role in our social life, by causing us to behave prosocially and facilitating social interaction. In line with its social function, it has been argued that imitation should be modulated by social factors relevant for social interaction and disrupted in people with social deficits, such as Autism Spectrum Disorder (ASD). However, research on both hypotheses has provided inconsistent results. We propose that these ...

A reliable and valid protocol for assessing action observation and imitation abilities in children with Developmental Coordination Disorder Hasselt University

Katrijn KLINGELS

Rehabilitation Research Center

BACKGROUND Action observation (AO) and imitation abilities are considered fundamental for learning and consolidating motor skills, but are often impaired in children with DCD. We recently developed a novel protocol for the assessment of AO and imitation abilities. AIMS (1) To confirm the psychometric properties of the protocol. (2) To compare AO and imitation abilities in children with DCD and aged-matched typically developing (TD) ...

Probing localised surface plasmon resonances in the TEM: overcoming the limitation of time-averaged intensity mapping with novel beam shaping methods. University of Antwerp

Johan Verbeeck

Electron microscopy for materials research (EMAT)

Small (submicron) metal particles interact with light in a peculiar way. Their optical properties (i.e. the colours of light they absorb or reflect) are determined by their size and shape, like the harmonics that define the sound of an organ pipe. The "harmonics" of a metal particle are called surface plasmon resonances (SPR). If SPRs can be correctly understood and harnessed, they offer the possibility to manipulate light as effectively as is ...

Neutrophils: neglected as potential players in autoimmune type 1 diabetes initiation, progression, and perpetuation KU Leuven

Chantal Mathieu

Clinical and Experimental Endocrinology

While the role of innate immune cells such macrophages and dendritic cells in the initiation and perpetuation of autoimmune type 1 diabetes (T1D) have been well documented, the particular actions of neutrophils remain unfairly overlooked in the etiology of this chronic disease. As neutrophils can influence cells of the innate and adaptive immune system, a better characterization of the neutrophil population during disease development is ...

Exploring the initiation and progression of NASH in a stem cell derived liver coculture model by revealing cellular stress activation pathways in real time Vrije Universiteit Brussel

Leo A van Grunsven

Basic (bio-) Medical Sciences

Non-alcoholic fatty liver disease (NAFLD) still remains a devastating
condition with no approved pharmaceutical therapy. To date, only four
candidate drugs have been able to reach Phase III clinical trials
aimed at reversing the progression of NAFLD to steatohepatitis, and
subsequently to hepatocellular carcinoma (HCC) or cirrhosis, and all
failed to receive approval. The main reason for the failure of
candidate ...

Elucidating the molecular dynamics of mammary tissue remodeling and tumor initiation using multiplexed biosensors in a novel branched mammary organoid system. KU Leuven

Colinda Scheele

Laboratory of Intravital Microscopy and Dynamics of Tumor Progression (VIB-KU Leuven)

The mammary gland is a branched organ that undergoes extensive remodeling throughout life. This remarkable regenerative ability of the mammary gland comes at a cost, as the extensive changes in proliferation and tissue architecture are also at the basis of progressive accumulation of oncogenic mutations. Although morphologically well described, the molecular pathways driving these morphological and functional changes are still poorly ...

Liver Fibrosis Initiation revisited Vrije Universiteit Brussel

Leo A van Grunsven

Basic (bio-) Medical Sciences

Liver fibrosis is the pathological condition of the liver resulting from
sustained wound healing in response to various causes of liver injury,
including chronic alcohol abuse, viral infections or obesity.
Liver disease remains a global issue, with an estimated death toll of
over 1.3 million deaths due to liver cirrhosis, the advanced form of
liver fibrosis. Fibrosis, or scarring of the liver, constitutes the
...

Structural snapshots of transcription initiation process by human and yeast mitochondrial RNA polymerases. KU Leuven

Kalyan Das

Laboratory of Virology and Chemotherapy (Rega Institute)

Transcription of genes are highly regulated process. The eukaryotic and bacterial gene transcription are accomplished by multi-subunit RNA polymerases (RNAPs). The mitochondrial genes are transcribed by single-subunit RNAPs. Regardless of differences in details, all RNAPs catalyze transcription initiation by a common sequence of events consisting of (i) promoter-specific recognition, (ii) formation of a transcription bubble, (iii) DNA ...

Tracing the dynamics of mammary tumor initiation. KU Leuven