In vitro and in vivo glyco-engineering of human IgG, and the leukocyte-cell surface with new fucosidasen Ghent University
Glycosylations on proteins are crucial to achieve correct protein folding, and outside the cell glycans perform numerous other functions. A very active area of research currently concerns the analysis of the role of complex sugars in the immune system1 . In particular, we want to explain how these sugars, and specifically fucose, are critical in both the effector function of antibodies and in the migration of leukocytes to specific sites ...