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Intermittent screening and treatment with artemether-lumefantrine versus intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in pregnancy: a facility-based, open-label, non-inferiority trial in Nigeria Institute of Tropical Medicine

Ekpereonne Esu, Nicole Berens-Riha, Michael Pritsch, Nuria Nwachuku, Thomas Loescher, Martin Meremikwu

BACKGROUND: The spread of SP resistance may compromise the effectiveness of intermittent preventive treatment of malaria in pregnancy (MiP) with sulfadoxine-pyrimethamine (IPTp-SP) across Africa. However, there is no recommended alternative medicine for IPTp or alternative strategy for prevention of MiP. This poses problems for the prevention of MiP. This study investigated, whether screening with a rapid diagnostic test for malaria at ...

Sulfadoxine-pyrimethamine resistance and intermittent preventive treatment during pregnancy: a retrospective analysis of birth weight data in the Democratic Republic of Congo (DRC) Institute of Tropical Medicine

JL Likwela, D'Alessandro, BL Lokwa, S Meuris, MW Dramaix
Objective: To assess the effect of intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) on birth weight in sites with varying degrees of drug resistance. Methods Birth weight data from three regions in Democratic Republic of Congo with varying degrees of sulfadoxine-pyrimethamine (SP) resistance (1.6% in Mikalayi, 21.7% in Kisangani and 60.6% in Rutshuru) were analysed retrospectively by means of a logistic model that ...

Evaluation of the usefulness of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine in a context with increased resistance of Plasmodium falciparum in Kingasani Hospital, Kinshasa in the Democratic Republic of Congo Ghent University

Nadine Kalenda Kayiba, Doudou Malekita Yobi, Vanessa Rodanis Kouoneyou Tchakounang, Dieudonné Makaba Mvumbi, Pius Zakayi Kabututu, Brecht Devleesschauwer, Erick Sompwe Mukomena, Patrick De Mol, Marie-Pierre Hayette, Georges Lelo Mvumbi, et al.
Background: Increasing resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine (SP) threatens its usefulness for intermittent preventive treatment in pregnancy (IPTp-SP). The prophylactic effects of IPTp-SP on maternal malaria and adverse pregnancy outcomes were evaluated in Kingasani Hospital, Kinshasa in the Democratic Republic of Congo (DRC). Methods: Laboring women (n = 844) and respective newborns were investigated. Blood samples ...

Bottlenecks for high coverage of intermittent preventive treatment in pregnancy: the case of adolescent pregnancies in rural Burkina Faso Institute of Tropical Medicine

Koen Peeters, Sabine Gies, SO Coulibaly, C Ky, J Somda, E. Toomer, Joan Muela Ribera, D'Alessandro
BACKGROUND: While IPTp-SP is currently being scaled up in sub-Saharan Africa (SSA), the coverage with the required >/=2 doses of SP remains considerably short of the Roll Back Malaria (RBM) goal of 80%, not to mention of the recently advocated universal coverage. METHODS: The study triangulates quantitative data from a health center randomized community-based trial on IPTp-SP effectiveness and the additional benefit of a promotional campaign ...

Community-based malaria screening and treatment for pregnant women receiving standard intermittent preventive treatment with sulfadoxine-pyrimethamine Vrije Universiteit Brussel

Susana Scott, Umberto d'Alessandro, Lindsay Kendall, John Bradley, Kalifa Bojang, Simon Correa, Fanta Njie, Halidou Tinto, Maminata Traore-Coulibaly, Hamtandi Magloire Natama, et al.

Background. We investigated whether adding community scheduled malaria screening and treatment (CSST) with artemether- lumefantrine by community health workers (CHWs) to standard intermittent preventive treatment in pregnancy with sulfadoxine- pyrimethamine (IPTp-SP) would improve maternal and infant health. Methods. In this 2-arm cluster-randomized, controlled trial, villages in Burkina Faso, The Gambia, and Benin were randomized to receive ...