Projects
Design and synthesis of inhibitors of the MEP pathway Ghent University
Fosmidomycin and multiple analogues of this natural phosphonate product demonstrate promising
antiplasmodial activitiy, but fail to show promising antibacterial activity even when the inhibitory
activity for bacterial and plasmodial DXR is comparable. This projects therefore aims at discovering
new DXR inhibitors with improved bacterial uptake by applying the eNTRy Rules and prodrug
strategies.
...Design, synthesis and biological evaluation of novel ferroptosis and necroptosis inhibitors. University of Antwerp
Design and development of new selective HDAC6 inhibitors with applications in cancer therapy Ghent University
This project will embark on the current interest in HDAC6 as a therapeutic target, aiming at the development and assessment of new HDAC6 inhibitors as potential novel clinical candidates for anticancer therapy. The research will include activities related to the design, synthesis and biological evaluation of new chemical entities as selective HDAC6 inhibitors on the one hand, and activities related to the assessment of the functional ...