Covalent locking of the influenza virus hemagglutinin prefusion structure: an innovative concept to create broadly protective influenza vaccines KU Leuven
Seasonal influenza causes each year a huge medical and economic burden. Though used since years to protect people at risk, the current influenza vaccines have important shortcomings such as modest efficacy, strain specificity and the need for yearly injection. There is an unmet need for broad (‘universal’) influenza vaccines that would solve these problems. One priority antigen is the prefusion stem domain of the viral hemagglutinin (HA). ...