Projects
The role of the 1,25(OH)2D3 signaling cascade and its analogs on inflammatory bowel disease KU Leuven
Inflammatory bowel disease (IBD) represents a group of idiopathic, chronic diseases of the gastro-intestinal tract including both Crohn’s disease (CD) and ulcerative colitis (UC). The exact etiology of IBD is still largely unknown, however, it is generally accepted that an excessive host immune response towards luminal bacteria plays a major role. A genetic predisposition, environmental factors as well as the epithelial barrier itself ...
Role of intestinal angiogenesis on the occurrence of extraintestinal articular manifestations in inflammatory bowel disease Ghent University
Recent data show that enhanced angiognesis is present in the affected bowel of patients with inflammatory bowel disease (IBD). By immunologic investigations on human bowel tissue and by animal research we want to further elucidate the role of angiogenesis in IBD. We also want ot investigate whether intestinal angiogenesis could be involved in the occurrence of articular manifestations in patients with IBD.
Gastroenterology > Inflammatory Bowel disease > personalised medicine; biomarkers; multi-omics KU Leuven
The role of snoRNAs in the etiology of inflammatory bowel disease KU Leuven
Targeting intestinal macrophages as new treatment for Inflammatory Bowel Disease. IBD-MAC. KU Leuven
Molecular profiling of early events in the pathogenesis of inflammatory bowel disease KU Leuven
Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gut and comprises two major forms: Crohn’s disease (CD) and ulcerative colitis (UC). A genetic predisposition is a risk factor for developing IBD, with a peak incidence in early adult life, and ranging beyond the sixth decade of life. It has been shown that the phenotypes of late-onset IBD differ from those in the younger population. Anti-tumor necrosis factor ...
Study of the mechanisms of action by which MUC1 and MUC13 affect the intestinal barrier upon inflammation in inflammatory bowel disease. University of Antwerp
Predicting the response to biological treatments in inflammatory bowel disease patients (PROBIP) Ghent University
With this grant application, we aim to verify and validate a test for the stratification of patients with inflammatory bowel diseases. In particular, we aim to:
- substantiate IP
- create a prediction model for the response to two therapeutic treatments and their validation
The interdependent role of metallothioneins and hypoxia-inducible factor and its relevance in experimental inflammatory bowel disease Ghent University
Metallothioneins (MTs) are proteins whose role in inflammatory bowel diseases (IBD) is only poorly understood. An aberrant expression of MTs in IBD patients has been demonstrated by our group. Recent data from literature provide evidence for an interrelationship between MTs and hypoxia. We wish to further elucidate the relationship between MTs and hypoxia and its functional relevance in IBD.