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Lumen enhancement influences absolute noncalcific plaque density on multislice computed tomography coronary angiography: ex-vivo validation and in-vivo demonstration Ghent University

Filippo Cademartiri, Giuseppe Runza, Alessandro Palumbo, Erica Maffei, Claudia Martini, Eugene P McFadden, Pamela Somers, Michiel Knaapen, Stefan Verheye, Annick Weustink, et al.
AIM: The purpose of this study was to define the in-vitro and in-vivo effects of intracoronary enhancement on the absolute density values of coronary plaques during multislice computed tomography. METHODS: We studied seven ex-vivo left coronary artery specimens surrounded by olive oil and filled with isotonic saline and four solutions with decreasing dilutions of contrast material: control (isotonic saline), 1/200, 1/80, 1/50, and 1/20. The ...

In-vitro and in-vivo evaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system Vrije Universiteit Brussel

Gerard Esteban, Jolien Van Schoors, Ping Sun, Ann Van Eeckhaut, José Marco-Contelles, Ilse Smolders, Mercedes Unzeta

OBJECTIVES: To evaluate the in-vitro and in-vivo effects on monoaminergic neurotransmission of ASS234, a promising multitarget-directed ligand (MTDL), for Alzheimer's disease (AD) therapy.

METHODS: In vitro was explored the effect of ASS234 on the monoaminergic metabolism in SH-SY5Y and PC12 cell lines, and remaining activity of both monoamine oxidase (MAO) isoforms was assessed. The corresponding dopamine (DA), homovanillic acid ...

Injectable phosphopullulan-functionalized calcium-silicate cement for pulp-tissue engineering: An in-vivo and ex-vivo study KU Leuven

Simón Pedano de Piero, Xin Li, Esther Hauben, Stéphanie De Vleeschauwer, Kirsten Van Landuyt, Bart Van Meerbeek
OBJECTIVE: To evaluate, by means of an ex-vivo human tooth-culture model and in-vivo minipig animal study, the pulpal inflammatory reaction and reparative dentin-formation capacity of an injectable phosphopullulan-based calcium-silicate cement (GC, Tokyo, Japan) upon pulp capping, this in comparison with the commercial reference material Biodentine (Septodont). METHODS: For the ex-vivo tooth model, 9 freshly-extracted teeth from 3 different ...

A Multi-method Approach towards Understanding the Pathophysiology of Aortic Dissections - The Complementary Role of In-Silico, In-Vitro and In-Vivo Information KU Leuven

Bart Bijnens
Management and follow-up of chronic aortic dissections continues to be a clinical challenge due to progressive aortic dilatation. To predict dilatation, guidelines suggest follow-up of the aortic diameter. However, dilatation is triggered by haemodynamic parameters (pressure and wall shear stresses (WSS)), and geometry of false (FL) and true lumen (TL). We aimed at a better understanding of TL and FL haemodynamics by performing in-silico (CFD) ...

Ex-vivo and in-vivo validation of a novel measuring protocol for guided endodontics KU Leuven

Simón Pedano de Piero, Paul Lambrechts, Reinhilde Jacobs
OBJECTIVES: To (1) validate the use of a post-operative intraoral scan (IOS) versus Cone Beam Computed Tomography (CBCT), gold standard, on its ability to measure the accuracy of guided endodontics, and (2) present clinical data on the accuracy of guided endodontics. METHODS: Four models, including 10 extracted teeth each, were created. Forty guided access cavities were planned on dentin to simulate pulp canal obliteration (PCO). Two operators ...

Uncoupling of in-vitro identity of embryonic limb derived skeletal progenitors and their in-vivo bone forming potential KU Leuven

Louca Verbeeck, Liesbet Geris, Przemko Tylzanowski, Frank Luyten
The healing of large bone defects remains a major unmet medical need. Our developmental engineering approach consists of the in vitro manufacturing of a living cartilage tissue construct that upon implantation forms bone by recapitulating an endochondral ossification process. Key to this strategy is the identification of the cells to produce such cartilage intermediates efficiently. We applied a cell selection strategy based on published ...

In-Vivo, In-Vitro and In-Silico methods for Small Molecule transfer across the BBB KU Leuven

Patrick Augustijns
The inability of molecules to permeate the BBB is a significant source of attrition in Central Nervous System (CNS) drug discovery. Given the increasing medical drivers for new and improved CNS drugs, small molecule transfer across the BBB is attracting a heightened awareness within pharmaceutical industry and medical fields. In order to assess the potential for small CNS molecules to permeate the BBB, a variety of methods and models, from in ...