Projects
Restoring defective regulators: a step towards an autologous regulatory T cell-based therapy for multiple sclerosis Hasselt University
Unraveling of the role and the regulation of hypoxia-inducible factors in natural killer cell functioning in hypoxic and stimulating environments. University of Antwerp
Evaluation of an anti-idiotype NanoCAR-T cell approach for the treatment of Multiple Myeloma Vrije Universiteit Brussel
The IRE1/XBP1 signaling axis in dendritic cell-mediated anti-tumor immune responses Ghent University
The aim of this project is to characterize the contribution of IRE1, a sensor of the unfolded protein response (UPR), in dendritic cells which present tumor derived antigens to CD8 T cells. A thorough understanding of the UPR in tumor antigen crosspresentation by dendritic cells is essential to improve current immunotherapies.
Eccentric: Enhancing the function of Cancer Countering Effector cells using Nanobodies Targeting Regulatory Immune Checkpoints Vrije Universiteit Brussel
Preclinical evaluation of THZ531-Nutlin-3 combination therapy to combat therapy-resistant neuroblastoma Ghent University
Neuroblastoma (NB) is a highly aggressive embryonal malignancy of the sympathetic nervous system. Despite
intensive multi-modal therapy, only half of high-risk patients survive while suffering from severe and long-term
treatment related side effects. While our discovery of ALK activating mutations opened the way to precision
...
Identification of cellular mechanisms of radiotherapy-induced immunogenicity Ghent University
Radiotherapy is widely used for the treatment of cancer, as half of
these patients will be considered throughout the course of their
treatment. Radiotherapy schedule is determined by several factors,
such as the tumor type, its localization in the body, or the protocols
established by the hospitals. In some rare cases, in which patients
have an outstanding clinical outcome, radiotherapy was shown to
induce ...