Projects
A quantitative analysis of varicella-zoster virus infection: from immunology to epidemiology. University of Antwerp
RAPTOR: a novel multi-view integrative framework to identify key features of T cell based immunology. University of Antwerp
The immunology of implantatio: the role of uterine dendritic cells Vrije Universiteit Brussel
Identification of the immunologic mechanism of action of an M2e-based influenza vaccine Ghent University
Protection against influenza A by vaccination with M2e-fusion constructs depends on antibodies. The aim is to determine the role of Fc receptors, antibody isotypes, macrophages and NK cells in this protection.
The development of preclinical models to evaluate combinatorial strategies for augmenting the potency of dendritic cell-based immunotherapy Vrije Universiteit Brussel
Two novel strategies are under development for the treatment of malignant melanoma: immunotherapy and molecular-targeted ...
Use of an integrative classification system and next-generation sequencing strategies for gene identification in common variable immunodeficiency disorder (CVID) Ghent University
Common variable immunodeficiency disorder (CVID) is a group of diseases in which the capacity to produce antibodies (immunoglobulins, Igs) against microbial infections is impaired. There is a marked decrease in one or more Ig classes and the number and/or function of certain B lymphocyte subsets may be reduced. In addition to an increased susceptibility to infections, CVID is also associated with auto-immune and malignant conditions. The ...
Multiple sclerosis, a multidisciplinary approach Hasselt University
Lipid-containing extracellular vesicles as mediators of remyelination and biomarkers in mutliple sclerosis Hasselt University
Dissecting the immunological and molecular mechanisms of gain-of-function NOD2 mutations in Blau Syndrome and Early Onset Sarcoidosis. KU Leuven
This work focuses on the identification of disease-causing genetic variants in paediatric patients with primary immunodeficiency (PID) and/or autoimmune/autoinflammatory disease. Although paediatric immune pathology is rare, these disorders are associated with a high morbidity and mortality and decreased quality of life. Treatment is often accompanied with serious side-effects and can hold risks on its own. Understanding the genetic cause of ...