Projects
Long non-coding RNA modulators of tumor immune evasion Ghent University
Each cell in our body contains a copy of our genetic material or DNA. DNA holds the blueprints for proteins, little machines that accomplish important processes in the cell such as regulating sugar intake, carrying oxygen etc. To make these protein machines, the information from the DNA blueprints is brought to the cell’s manufacturing plant through an intermediate molecule called messenger RNA. A decade ago, we discovered that a lot of RNAs ...
INVISIBLE: Investigation and inhibition of Epstein-Barr Virus immune evasion by BILF1-modulating nanobodies Vrije Universiteit Brussel
around 90% of the worldwide population. Although primary EBV
infections are usually asymptomatic in healthy individuals, EBV has
been found in several cancers including B cell lymphomas. While the
exact role of EBV in these tumors is not fully understood, EBV
infection is suggested to result in a more immunosuppressive tumor
microenvironment ...
Immunoediting and immune evasion mechanisms in the treated and untreated cancer genome Ghent University
Tumour-immune interactions during tumour evolution result in immunoediting and immune evasion. The goal of this project is to use large cancer genome databases to identify the underlying genomic alterations, in both the untreated cancer genome and following treatment with immunomodulating agents. Results can be exploited to predict differential responses to cancer immunotherapy.
Herpesvirus interactions with cellular signaling pathways, and their consequences for virus immune evasion and spread. Ghent University
Viruses are obligate intracellular pathogens. To be able to replicate in cells, spread to other cells, and avoid or delay elimination by the immune system, viruses have developed several, largely incompletely understood, interactions with cellular signaling pathways. The aim of this project is to obtain more insights in these interactions for herpesviruses.
Role of viral glycans and siglec receptors for infection of macrophages and viral immune evasion Ghent University
The role of different siglec receptors for viral infection of macrophages and the potential role of siglec-specific virus internatlization for immune evasion will be studied.
Exploring the role of microbiome-immune interactions in colorectal cancer development and immune evasion KU Leuven
Cancer is a highly prevalent and life-threatening disease, and somehow the tumors escape the immune system what makes treatment more difficult. Current therapies therefore focus on reactivating the immune system to clear the tumor. This seems successful to treat several cancer types, however not in the treatment of colorectal cancer (CRC). CRC tumors thus have likely an additional way of escaping the immune system that might be associated ...
Immune evasion of eqiune herpesvirus type 1 Ghent University
Equine herpesvirus type 1 or EHV-1 is a constant treat to horses worldwide. Rationally modifying genes which are involved in immune modulation, and elucidating the effects of such modifications on the degree of immune protection, are indispensable for the design and generation of efficacious and safe modified live vaccines against infections with EHV-1.