Publications
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Hypoxia enhances the relaxing influence of perivascular adipose tissue in isolated mice aorta Ghent University
Dietary teprenone enhances non-specific immunity, antioxidative response and resistance to hypoxia induced oxidative stress in Lateolabrax maculatus Ghent University
Hypoxia, microsatellite alterations and promoter hypermethylation in HNSCC: interplay and biomarker potential KU Leuven
Spinocellulaire hoofd-en halscarcinomen (SCCHH) zijn de zesde meest voorkomende niet-hematologische maligniteiten met een incidentie van meer dan 600.000 patiënten per jaar. Ondanks recent doorgevoerde optimalizaties van de drie bestaande behandelingspijlers chirurgie, chemotherapie en radiotherapie blijven SCCHH een belangrijke oorzaak van kanker- en therapie-gerelateerde morbiditeit en mortaliteit. Het invoeren van nieuwe ...
The combined effect of hypoxia and nutritional status on metabolic and ionoregulatory responses of common carp (**Cyprinus carpio**) University of Antwerp
Since hypoxia is a common event in aquatic environments, oxygen has been a major driving force in the evolution of fish. When fish are simultaneously faced with food deprivation in their natural habitat, this poses an even greater challenge to energy and ion homeostasis. In the present study, the combined effects of hypoxia and nutritional status (fed versus fasted) were examined in common carp (Cyprinus carpio), a relatively hypoxia tolerant ...
A Seven-Gene Set Associated with Chronic Hypoxia of Prognostic Importance in Hepatocellular Carcinoma KU Leuven Ghent University
PURPOSE: Hepatocellular carcinomas (HCC) have an unpredictable clinical course, and molecular classification could provide better insights into prognosis and patient-directed therapy. We hypothesized that in HCC, certain microenvironmental regions exist with a characteristic gene expression related to chronic hypoxia which would induce aggressive behavior. EXPERIMENTAL DESIGN: We determined the gene expression pattern for human HepG2 liver cells ...
Hypoxia Promotes Dissemination of Multiple Myeloma Through Acquisition of Endothelial to Mesenchymal Transition (EMT) Features Vrije Universiteit Brussel
Multiple myeloma (MM) is characterized by widespread dissemination of the MM cells at diagnosis associated with multiple focal bone lesions, implying (re)circulation of MM cells into the peripheral blood and (re)entrance or homing into new sites of the BM. However, the driving force for MM cells to leave the BM, egress, and home to new BM niches is still not well understood. Hypoxia (low oxygen) in solid tumors was shown to promote metastasis in ...
Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA) University of Antwerp
Purpose The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. Methods Cohort of the European Sleep Apnea ...
Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling KU Leuven
Hypoxia is linked to therapeutic resistance and poor clinical prognosis for many tumor entities, including human papillomavirus (HPV)-positive cancers. Notably, HPV-positive cancer cells can induce a dormant state under hypoxia, characterized by a reversible growth arrest and strong repression of viral E6/E7 oncogene expression, which could contribute to therapy resistance, immune evasion and tumor recurrence. The present work aimed to gain ...