Publications
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Hypoxia, hypoxia inducible factor 1 (HIF-1) and tumour biology University of Antwerp
A multi-proxy approach to reconstruct hypoxia on the NW Black Sea shelf over the Holocene Ghent University
Coastal hypoxia is a worldwide concern. Even though seasonal hypoxia has been reported on the northwestern Black Sea shelf since the 1970s, little is known about oxygenation in this area over the Holocene. With a multiproxy approach, this work aimed to detect potential hypoxic events in two gravity cores. Our results demonstrate that the most common proxies of hypoxia are irrelevant for the Black Sea coastal environment. For instance, the ...
Multiple myeloma cells antagonize hypoxia induced cell death through upregulation bcl-2 and bcl-xl Vrije Universiteit Brussel
Background. Hypoxia, a condition of decreased availability of oxygen, is major challenge for anticancer therapy. In solid tumors, hypoxia is considered as a double-edged sword: on the one hand, cells can be irreversibly injured and die under conditions of oxygen deficiency; on the other hand, cells that become adaptive to hypoxia are more resistant to apoptosis and less responsive to cancer therapy, resulting in relapse of the disease and ...
Separate and Combined Effects of Hypoxia and Horizontal Bed Rest on Retinal Blood Vessel Diameters Hasselt University
PURPOSE: To assess the separate and combined effects of exposure to prolonged and sustained recumbency (bed rest) and hypoxia on retinal microcirculation. METHODS: Eleven healthy male subjects (mean ± SD age = 27 ± 6 years; body mass index [BMI] = 23.7 ± 3.0 kg m-2) participated in a repeated-measures crossover design study comprising three 21-day interventions: normoxic bed rest (NBR; partial pressure of inspired O2, PiO2 = 133.1 ± 0.3 mm Hg); ...
Is Hypoxia Related to External Cervical Resorption? A Case Report Hasselt University KU Leuven
Despite the fact that external cervical resorption (ECR) is a well-known and rather frequently met condition, the driving force of this phenomenon still remains unclear. Recently, hypoxia has been linked to ECR. Thus, the aim of this work was to investigate the existence of hypoxia in ECR and hypothesize on its role at the time of extraction. This work is a case study of a tooth with ECR. ECR diagnosis was based on clinical and radiographic ...
Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models Vrije Universiteit Brussel
UNLABELLED: The availability of (18)F-labeled and unlabeled 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5) allows for a comparative assessment of tumor hypoxia by PET and immunohistochemistry; however, the combined use of these 2 approaches has not been fully assessed in vivo. The aim of this study was to evaluate (18)F-EF5 tumor uptake versus EF5 binding and hypoxia as determined from immunohistochemistry at ...
Comparison of the hypoxia PET tracer 18F-EF5 to immunohistochemical marker EF5 in 3 different human tumor xenograft models Vrije Universiteit Brussel
The availability of 18F-labeled and unlabeled 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5) allows for a comparative assessment of tumor hypoxia by PET and immunohistochemistry; however, the combined use of these 2 approaches has not been fully assessed in vivo. The aim of this study was to evaluate 18F-EF5 tumor uptake versus EF5 binding and hypoxia as determined from immunohistochemistry at both macroscopic and ...
Hypoxia and tumor-associated macrophages : a deadly alliance in support of tumor progression Vrije Universiteit Brussel
Tumor-associated macrophages (TAMs) provide a significant contribution to tumor growth and metastasis. We demonstrated the existence of two main TAM subsets, differing in activation state and localization. Of these, M2-like TAMs reside in hypoxic regions of the tumor mass and can be used as targets for hypoxia tracers. This said, hypoxia does not regulate the differentiation of TAMs but finely tunes the activity of the M2-like population.
IFN-γ+ CD8+ T lymphocytes: a possible link between immune and radiation responses in tumor-relevant hypoxia. Vrije Universiteit Brussel
Activated T lymphocytes are known to kill tumor cells by triggering cytolytic mechanisms; however, their ability to enhance radiation responses remains unclear. This study examined the radiosensitizing potential of mouse CD8+ T cells, obtained by T-cell-tailored expansion and immunomagnetic purification. Activated CD8+ T cells displayed an interferon (IFN)-gamma+ phenotype and enhanced by 1.8-fold the radiosensitivity of EMT-6 tumor cells in 1% ...