Projects
Assessing the potential dual beneficial effects on bone health and global energy metabolism of hypoxia signaling pathway modulation KU Leuven
Metabolic disorders as osteoporosis, obesity and diabetes represent common comorbidities associated with poor bone quality and impaired fracture repair affecting increasing numbers of people. Interestingly, the host lab recently found that genetic activation of hypoxia signaling in osteolineage cells led to improved systemic glucose homeostasis, along with increased bone mass and vascularisation. This raises the intriguing hypothesis that ...
Improving cancer immunotherapy outcome by targeting hypoxia. University of Antwerp
Regulation of the central metabolism of pear during hypoxia KU Leuven
Quantitative nuclear magnetic resonance imaging for characterization of biological parameters with applications in cancer treatment using ionizing radiation. Ghent University
The aim of this study is to visualize two physiological quantities in a non-invasive way using nuclear magnetic resonance imaging: (1) cel biological changes that are the result of ionizing radiation and (2) the oxygen distribution in tumours. This kind of biological imaging can be applied in the study of radiation therapy using hadrons and in optimizing cancer treatment (hypoxia).
Quantitative nuclear magnetic resonance imaging for characterization of biological parameters with applications in cancer treatment using ionizing radiation Ghent University
The aim of this study is to visualize two physiological quantities in a non-invasive way using nuclear magnetic resonance imaging: (1) cel biological changes that are the result of ionizing radiation and (2) the oxygen distribution in tumours. This kind of biological imaging can be applied in the study of radiation therapy using hadrons and in optimizing cancer treatment (hypoxia).
Method development for multi-modal imaging mass spectrometry (LA-ICP-MS and MALDI-MS): fusing elemental with molecular information to gain insight into hypoxia-driven processes in cancer Ghent University
Tumor hypoxia is one of the hallmarks of cancer and has turned into a central issue in cancer treatment since it is associated with malignant tumor progression, resistance to therapy and increased metastatic spread. To date, many aspects of hypoxia-induced changes in tumors remain to be elucidated. This drives the need to develop multi-modal imaging workflows for discovering and identifying key biomolecules in the heterogeneous tumor ...
Molecular imaging and molecular profiling for head, neck, lung and rectal cancer MRT: application in dose-painting and response prediction. Ghent University
The KUL-UCL-UG consortium has been contributing since 2003 (thanks to the support of the Foundation against Cancer) to validate the use of molecular imaging in Target Volume (TV) delineation for the treatment of head and neck (H1N), and rectal cancers. In line with the previous researchprojects, the general aim of the study proposal is: 1) to validate the dose-painting approach to escalate radiation dose on TV(s) delineated onPET images using ...