Longitudinal measurement of synaptic density to monitor progression of Parkinson's disease and Huntington's disease KU Leuven
Increasing evidence from cell or animal models and postmortem human studies suggests that synaptic pathology is important in the early disease pathophysiology of Parkinson’s (PD) and Huntington’s disease (HD). PET imaging with 11C‑UCB‑J, targeting the presynaptic protein SV2A, provides an in vivo marker for synaptic density in the human brain. This thesis reports two multimodal imaging studies in people with early PD and early HD ...