Calcineurin inhibitor-free immunosuppressive regimen in type 1 diabetes patients receiving islet transplantation Vrije Universiteit Brussel
BACKGROUND: Our final objective is to develop an adoptive therapy with tolerogenic donor-specific type 1 T regulatory cells for patients with type 1 diabetes undergoing islet transplantation. The achievement of this objective depends on the availability of an immunosuppressive treatment compatible with the survival, function, and expansion of type 1 T regulatory cells.
METHODS: For this purpose, we designed a single-group, phase 1 to 2 ...