Projects
Building in vivo human neuronal models of neurodevelopmental diseases. KU Leuven
Functional connectivity and oscillatory neuronal activity in the human brain KU Leuven
Perception, cognition and behaviour are achieved through the coordination of multiple brain regions, which exchange information between each other. Despite enormous recent progress, our understanding of the dynamic long−range neuronal communication between distant regions in the brain is still very limited. In this project we will develop a methodology for imaging brain networks using electroencephalography, which provides a direct measure of ...
The early embryonic function of TET DNA dioxygenases in human neurulation and disease. KU Leuven
TET family dioxygenases erase DNA methylation. Loss of Tet1 in the pre-gastrulation mouse epiblast causes dysregulation of chromatin accessibility and DNA methylation at neural fate genes prior to their gene activation in development, resulting in congenital and post-natal neurodevelopmental disorders in mutant mice. Here, we aim to extend our findings from mouse to human development, by exploiting in vitro differentiation of human embryonic ...