Electrophysiological study of human iPSC differentiated neurons. KU Leuven
This project aims to investigate electrophysiologically how human neurons differentiated from iPSC can function as a model system for ALS-FTD.
This project aims to investigate electrophysiologically how human neurons differentiated from iPSC can function as a model system for ALS-FTD.
The human brain is characterized by its unique features, but the underlying developmental origins remain largely unknown. One important mechanism could be the unusually protracted rates of maturation of human cortical neurons, leading to neoteny of specific neuronal populations in the human cortex, compared with nonhuman primates (NHP). Very little is known about human neuronal neoteny, but interestingly it is also observed in human cortical ...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, characterized by the loss of motor neurons. Accumulation of insoluble TDP-43 is a hallmark of the disease. Using induced pluripotent stem cells (iPSCs), obtained from ALS patients with an underlying mutation in the gene encoding TDP-43, we investigate the disease mechanisms of motor neuron degeneration. The iPSCs are differentiated into motor neurons, and the disturbance of ...
The aim of this multidisciplinary project is to create a new 3D human neuromuscular circuit that resembles as close as possible the human situation. Therefore, we will culture motor neurons starting from induced pluripotent stem cells (iPCS) derived from skin biopsies of patients and healthy volunteers and combine these cells with myotubes derived from human satellite cells or iPSCs. We will develop new microfluidic devices which will allow ...
Autism is a severe neurodevelopmental disorder. It belongs to a group of pervasive developmental disorders with a prevalence of 0,7%. Autism spectrum disorders are diagnosed purely on clinical grounds by impairment in social interactions and communication and repetitive, stereotyped patterns of behaviour and interests. Twin and family studies indicate a strong genetic contribution to the aetiology of autism, although environmental causes are ...
The human brain is characterized by unique cognitive features, but the underlying developmental origins remain largely unknown. One important mechanism could be the unusually slow rates of maturation of human cortical neurons, leading to a so-called neoteny of specific neuronal populations in the human cortex, compared with non-human primates. Very little is known about the mechanisms underlying the speed of maturation of neurons, but it is ...