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The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps. Vrije Universiteit Brussel

N. Holland, C. Bolognesi, Micheline Volders, S. Bonassi, E. Zeiger, S Knasmueller, M. Fenech
The micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. This overview has concluded that although MN assay in buccal cells has been used since the 1980s to demonstrate cytogenetic effects of environmental and occupational exposures, lifestyle factors, dietary deficiencies, and different diseases, important knowledge gaps remain about the characteristics of ...

Interpreting biomonitoring data: introducing the international human biomonitoring (i-HBM) working group's health-based guidance value (HB2GV) dashboard University of Antwerp KU Leuven

Shoji F. Nakayama, Annie St-Amand, Tyler Pollock, Petra Apel, Yu Ait Bamai, Dana Boyd Barr, Jos Bessems, Antonia M. Calafat, Argelia Castano, Adrian Covaci, et al.
Human biomonitoring (HBM) data measured in specific contexts or populations provide information for comparing population exposures. There are numerous health-based biomonitoring guidance values, but to locate these values, interested parties need to seek them out individually from publications, governmental reports, websites and other sources. Until now, there has been no central, international repository for this information. Thus, a tool is ...

Translating biomonitoring data into risk management and policy implementation options for a European Network on Human Biomonitoring University of Antwerp

Roel Smolders, G. Koppen, Greta Schoeters
Background The "European Environment & Health Action Plan 20042010" originates from the concern of the European Commission on the well-being of individuals and the general population. Through this plan, the Commission has set the objectives to improve the information chain for a better understanding of the link between sources of pollution and health effects, to better identify existing knowledge gaps, and improve policy making and ...

Human exposure pathways to organophosphate flame retardants: Associations between human biomonitoring and external exposure University of Antwerp

Fuchao Xu, Igor Eulaers, Andreia Alves, Eleni Papadopoulou, Juan Antonio Padilla-Sanchez, Foon Yin Lai, Line Smastuen Haug, Stefan Voorspoels, Hugo Neels, Adrian Covaci, et al.
Organophosphate flame retardants (PFRs) have largely replaced the market of polybrominated diphenyl ethers (PBDEs). Concerns about PFR contamination and its impact on human health have consequently increased. A comprehensive investigation on the human exposure pathways to PFRs is to be endeavoured. This study investigated the occurrence of PFR metabolites in human urine, serum and hair, correlating them with external exposure data that was ...

Biomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative University of Antwerp

Katrin Vorkamp, Argelia Castano, Jean-Philippe Antignac, Luis D. Boada, Enrique Cequier, Adrian Covaci, Marta Esteban Lopez, Line S. Haug, Monika Kasper-Sonnenberg, Holger M. Koch, et al.
The major purpose of human biomonitoring is the mapping and assessment of human exposure to chemicals. The European initiative HBM4EU has prioritized seven substance groups and two metals relevant for human exposure: Phthalates and substitutes (1,2-cyclohexane dicarboxylic acid diisononyl ester, DINCH), bisphenols, per and polyfluoroalkyl substances (PFASs), halogenated and organophosphorous flame retardants (HFRs and OPFRs), polycyclic aromatic ...