Projects
Epi(genetic) stability in gametes, preimplantation embryos and human embryonic stem cells with a focus on the behaviour of dynamic mutations causing myotonic dystrophy and fragile X syndrome Vrije Universiteit Brussel
Insights in the adaptive character of extra-pair paternity behaviour across human Western populations KU Leuven
When the caring and official father is not the biological one, a so-called extra-pair paternity (EPP) event occurs. After decades of speculation and many false or highly biased claims, data on EPP frequencies within contemporary human populations became available in the last decade. Although highly relevant for biologists, social scientists and forensic geneticists, estimations of EPP frequencies in past populations still remain controversial ...
Behavior monitoring and unusual human activity with multiple cameras Ghent University
Why white matter matters: a multimodal investigation towards a better understanding of its role and function in human motor behavior KU Leuven
In many daily life activities such as buttoning up a blouse, tying your shoelaces or washing your hair, excellent coordination between the hands is crucial. During such movements, good collaboration (i.e., communication) within and between both sides of the brain is of great importance. This neural communication is accomplished via WM pathways (structural connectivity) and functional interactions between relevant brain areas (functional ...
The role of behavioural architecture in the evolution of human social heuristics KU Leuven
Humans often make seemingly suboptimal social decisions, such as incurring a cost to help strangers they will never see again. Standard economic and evolutionary theories have difficulty explaining this, because they typically assume that behavioural responses are specifically tailored to each situation that may arise. This ignores the fact that humans face many different social situations that they cannot perfectly assess, and that the ...
An examination instruction based learning purposeful behavior in the human brain Ghent University
This project will investigate the neural mechanisms that underpin our ability to learn novel behavior via instruction. Different neuroscience methods will be applied, including functional brain imaging, electrophysiology, and non-invasive brain stimulation, to capture complementary aspects of neural information processing. This integrative approach will likely yield novel and important insights into the human brain’s unique capacity for ...
Impact of the dynamic nature of the human gastrointestinal tract on drug and formulation behavior. KU Leuven
Authorized drugs intended for oral administration often suffer from suboptimal or variable performance in clinical practice. In addition, many promising drug candidates fail during costly and time-consuming clinical trials. An important cause of these problems is a poor prediction of intestinal drug absorption. While the pharmaceutical industry expresses an urgent need for more predictive simulation tools, their development requires a ...
Towards a deeper understanding of physiological factors affecting drug and formulation behavior in the human gastrointestinal tract KU Leuven
Intraluminal profiling is a successful technique which allows you to measure drug concentrations in the gastrointestinal (GI) tract as a function of time by aspiration of fluids in the stomach and upper small intestine (i.e. duodenum). Although these studies assisted us to unravel the intestinal behavior of selected oral medicines, it was not always straightforward to correlate the gastrointestinal behavior of the drug with concentrations ...