Projects
Human germline gene editing to overcome transmission of infertility: a proof-of-concept study Ghent University
The recent development of the CRISPR/Cas9 technology as a versatile and efficient tool has enabled human germline gene editing and can be applied to correct abnormal DNA sequences during fertilization. However, its future implementation for therapeutic approaches is still heavily debated, not only from an ethical perspective, but also because many uncertainties regarding the safety and efficiency of the technique still exist. More ...
Development of a decision support grid regarding human and environmental exposure to herbicides and insecticides Research Institute for Agriculture, Fisheries and Food
In five case studies (beet cultivation, pome fruit cultivation, arable land/grassland, railway verges and non-public pavements), the Decalpe project aims to provide an answer to the question whether or not the ban on the use of glyphosate and neonicotinoids leads to a higher risk of human and environmental exposure to other herbicides and insecticides. In addition, a decision support grid is ...
Development of a human induced pluripotent stem cell-derived 3D liver NAFLD culture model. Vrije Universiteit Brussel
Human Computer Communication: Dialogue System KU Leuven
Dialog systems are usually divided into two categories: chitchat (Cho and Julien, 2016) and task comple- tion dialogue system (Wen et al., 2016b). These systems have an increasing effect in social and industrial life. Via either auditory or textual input, people communicate with machines in natural language for task completion or daily entertainment. Usually, chitchat systems are designed to meet the mental needs of the user, such as mental ...
Comprehensive investigation of mycotoxin exposure biomarkers by using metabolomics to elucidate mycotoxin human toxicokinetics Ghent University
Biomarker analysis has been proposed to assess human exposure to xenobiotics by using concentrations of the parent compounds and/or metabolites in biological matrices. However, the gap of information on human mycotoxin absorption and excretion profiles generates many discrepancies to link mycotoxin (biomarkers) concentrations found in biological fluids with the mycotoxin dietary intake. Toxicokinetic studies permit to elucidate the process of ...
Toward a relational fame theory account of human psychopathology within a functional-cognitive framwork Ghent University
The overarching aim of the project is to develop a functional account of human psychopathology, which is embedded within a functional-cognitive meta-theoretical framework. This framework entails that the cognitive and functional approaches in psychology are mutually supportive. Whereas functional research on psychopathology may provide data that need to be explained at the cognitive level, cognitive theorising may generate new predictions at ...
Regenerative strategies with human amniotic fluid stem cells for neonatal disorders KU Leuven
Cell therapeutic approaches are fast emerging in human medicine, potentially enabling novel therapies for patients. Stem cells could be clinically translated for the replacement or repair of damaged or diseased structures, or the restoration of a normal organ’s function.
In this doctoral research, we explored the use of amniotic fluid-derived mesenchymal stem cells (AF-MSC) as a cell therapeutic tool in a perinatal setting, focusing on ...
Intensive identification of human pathogenic shigatoxin producting Escherichia coli (STEC) in Belgium Research Institute for Agriculture, Fisheries and Food
The first aim of the IDESTEC project is to develop an effective method for the detection and isolation of STEC (Shiga toxin-Producing E. coli) from food of animal and plant origin, using classical microbiological and molecular techniques. Second is the genetic characterization of a large collection of STEC strains (national and international) in order to identify related isolates, detect ...