Cystic fibrosis as a modulable model for host – microorganism interactions in airway disease. Ghent University
The pathophysiology of inflammatory airway diseases and their exacerbations is determined by a continuous interplay of (1) airway microenvironment, (2) its microbial co-inhabitants, and (3) host immune response. The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes for an ion channel involved in the pathogenesis of many chronic airway diseases. In cystic fibrosis (CF), an autosomal recessive trait in CFTR leads to thick ...