SUBSTRATE MAPPING AND ACTIVITY REGULATION OF PP1 HOLOENZYMES KU Leuven
Protein phosphatase 1 (PP1) is an essential protein Ser/Thr phosphatase, which regulates various cellular processes in eukaryotic cells. The activity and substrate specificity of PP1 is strictly controlled by associated polypeptides, which are known as Regulatory Interactors of Protein Phosphatase One (RIPPOs). Currently, more than 200 RIPPOs have been described, all acting as subcellular targeting subunits, substrate recruiters, and/or ...