Projects
Integration of cellular signaling pathways in health and disease. KU Leuven
Uncovering regulators of H3K79 methylation in cartilage to identify targets for osteoarthritis therapy KU Leuven
Osteoarthritis (OA), the most common chronic joint disease, is characterized by progressive damage to the articular cartilage, remodelling of the joint-associated bone, and inflammation. Current OA treatments are limited to pain relief, physiotherapy, or joint replacement surgery in severe cases, yet drugs that stop the disease progression are lacking. DOT1L is an enzyme that chemically modifies an amino-acid (Lysine at position 79) in the ...
Proteolytical histone processing during human stem cell differentiation Ghent University
Epigenetic modifications of chromatin are essential in the regulation of many biological
processes. The evolutionary conserved histone proteins that are intimately associated with
DNA to form the chromatin are pivotal epigenetic substrates herein. The amino-terminal tail
of these histones protrudes from the nucleosome and can become modified by many different
posttranslational modifications on at least 60 different ...