Publications
Next-generation sequencing in prenatal setting Vrije Universiteit Brussel KU Leuven
The application of next-generation sequencing to fetal pathology has proved to increase the diagnostic yield in fetuses with abnormal ultrasounds. We retrospectively reviewed genetic data of 30 selected cases studied through targeted resequencing of OMIM genes. In our experience, clinical data proved to be essential to support diagnostic reasoning and enhance variants' assessment. The molecular diagnosis was reached in 19/30 (63%) cases. Only ...
A hidden Markov-model for gene mapping based on whole-genome next generation sequencing data Hasselt University
SNP Discovery Using Next Generation Transcriptomic Sequencing in Atlantic Herring (Clupea harengus) KU Leuven
Applications of nanopore sequencing for forensic analysis Ghent University
CSYseq: The first Y-chromosome sequencing tool typing a large number of Y-SNPs and Y-STRs to unravel worldwide human population genetics KU Leuven
Using plant virology high throughput sequencing data in screening for other potential plant pathogens Research Institute for Agriculture, Fisheries and Food
Nanopore sequencing for Mycobacterium tuberculosis University of Antwerp
Quality evaluation of methyl binding domain based kits for enrichment DNA-methylation sequencing Ghent University
IPED Institute of Tropical Medicine KU Leuven Vrije Universiteit Brussel
BACKGROUND: The development of high-throughput sequencing technologies has revolutionized the field of microbial ecology via the sequencing of phylogenetic marker genes (e.g. 16S rRNA gene amplicon sequencing). Denoising, the removal of sequencing errors, is an important step in preprocessing amplicon sequencing data. The increasing popularity of the Illumina MiSeq platform for these applications requires the development of appropriate ...