Fat primes the liver for hepatocellular carcinoma development by inducing a Warburg metabolism KU Leuven
Hepatocellular carcinoma (HCC) is one of the most common and deadliest cancers worldwide, with an overall mortality rate of 93%. A major risk factor for HCC development is obesity with concomitant insulin resistance. Already today 30% of all HCC cases are related to obesity and insulin resistance. However, obesity and insulin resistance by their own are not sufficient to drive HCC development in mice. Surprisingly, the combination of ...