Unravelling the crosstalk between Stellate cells and Kupffer cells and its role in maintaining Stellate cell quiescence Ghent University
Activated stellate cells are the main driver of fibrosis. The signals that convert quiescent stellate cells into pathogenic myofibroblasts remain largely unknown. Spatial analysis has revealed that each quiescent stellate cell is paired with a Kupffer cell (KC) in the steady-state liver. Upon KC depletion, stellate cells promote the recruitment of monocytes and their differentiation into KCs through the production of instructive signals. In ...