Projects
Modulation of liver fibrosis by liposome-mediated selective targeting of hepatic stellate cells Vrije Universiteit Brussel
Unravelling the crosstalk between Stellate cells and Kupffer cells and its role in maintaining Stellate cell quiescence Ghent University
Activated stellate cells are the main driver of fibrosis. The signals that convert quiescent stellate cells into pathogenic myofibroblasts remain largely unknown. Spatial analysis has revealed that each quiescent stellate cell is paired with a Kupffer cell (KC) in the steady-state liver. Upon KC depletion, stellate cells promote the recruitment of monocytes and their differentiation into KCs through the production of instructive signals. In ...
Human liver disease: Study of the hepatic stem cells and their niche, and development of novel model systems Vrije Universiteit Brussel
HeMiBio - Hepatic Microfluidic Bioreactor. KU Leuven
Liver progenitor cells, their secretome and liver repair Vrije Universiteit Brussel
Myotonic dystrophy type 1 (DM1)-specific induced pluripotent stem cells (iPS): an innovative platform for myogenic and cardiomyogenic differentiation and validation of novel therapeutic approaches Vrije Universiteit Brussel
The link between hypoxia and progenitor cells during liver carcinogenesis Vrije Universiteit Brussel
In vitro functional formation of liver sinusoidal endothelial cells in 3D culture system. KU Leuven
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells that form the barrier between the blood and hepatocytes and hepatic stellate cells (HSCs). LSECs lack a basement membrane and are fenestrated, allowing macromolecule transport across this barrier. In liver inflammation, LSECs dedifferentiate (also called sinusoidal capillarization), form a basement membrane and lose fenestrae, which further promotes fibrosis. ...
HeMiBio (related to project EU376-B) Vrije Universiteit Brussel
In the project we made the following advances beyond the state of the art:
1. CELLS: We characterized for the first ...