Publications
MicroRNA-223 restricts liver fibrosis by inhibiting the TAZ-IHH-GLI2 and PDGF signaling pathways via the crosstalk of multiple liver cell types Vrije Universiteit Brussel
Background & Aims: Liver fibrosis is a common consequence of chronic liver injury and is characterized by the accumulation of extracellular matrix mainly generated from activated hepatic stellate cells (HSCs). At present, the mechanisms underlying liver fibrogenesis remain obscure and effective pharmacological therapies are lacking. Neutrophil-specific microRNA-223 (miR-223) plays an important role in controlling the development of ...
Patched 1 Expression Correlates with Biochemical Relapse in High-Risk Prostate Cancer Patients KU Leuven
Wnt signaling and the control of human stem cell fate University of Antwerp
Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells. Vrije Universiteit Brussel
Bone Disease in Axial Spondyloarthritis KU Leuven
Bone Disease in Axial Spondyloarthritis KU Leuven
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma University of Antwerp
Retinoid signaling in pancreatic cancer, injury and regeneration Vrije Universiteit Brussel
BACKGROUND: Activation of embryonic signaling pathways quiescent in the adult pancreas is a feature of pancreatic cancer (PC). These discoveries have led to the development of novel inhibitors of pathways such as Notch and Hedgehog signaling that are currently in early phase clinical trials in the treatment of several cancer types. Retinoid signaling is also essential for pancreatic development, and retinoid therapy is used successfully in ...