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Malnutrition risk and frailty in head and neck cancer patients Vrije Universiteit Brussel

Priya Dewansingh, Linda Bras, Lies Ter Beek, Jan L N Roodenburg, Cees P. van der Schans, Gyorgy B Halmos, Harriët Jager-Wittenaar

PURPOSE: Both malnutrition and frailty are associated with adverse treatment outcomes. Malnutrition (risk) and frailty are each commonly present in patients with head and neck cancer (HNC). However, their coexistence and association is unknown. Main goal of this study is to determine the coexistence of, and the association between malnutrition risk and frailty in patients with HNC.

METHODS: In this retrospective analysis on ...

Exhaled breath analysis in the diagnosis of head and neck cancer KU Leuven

Vincent Vander Poorten
Head and neck cancer (HNC) comprises a heterogeneous group of upper aerodigestive tract malignant neoplasms, the most frequent of which is squamous cell carcinoma. HNC forms the eighth most common cancer type and the incidence is increasing. However, survival has improved only moderately during the past decades. Currently, early diagnosis remains the mainstay for improving treatment outcomes in this patient population. Unfortunately, screening ...

A Monte Carlo based scatter removal method for non-isocentric cone-beam CT acquisitions using a deep convolutional autoencoder Ghent University

Brent van der Heyden, M. Uray, G. P. Fonseca, P. Huber, D. Us, I. Messner, A. Law, A. Parii, N. Reisz, I. Rinaldi, et al.
The primary cone-beam computed tomography (CBCT) imaging beam scatters inside the patient and produces a contaminating photon fluence that is registered by the detector. Scattered photons cause artifacts in the image reconstruction, and are partially responsible for the inferior image quality compared to diagnostic fan-beam CT. In this work, a deep convolutional autoencoder (DCAE) and projection-based scatter removal algorithm were constructed ...

A literature review of the potential diagnostic biomarkers of head and neck neoplasms University of Antwerp Ghent University

Heleen Konings, Sofie Stappers, Margot Geens, Benedicte De Winter, Kevin Lamote, Jan van Meerbeeck, Pol Specenier, Olivier Vanderveken, Kristien Ledeganck
Head and neck neoplasms have a poor prognosis because of their late diagnosis. Finding a biomarker to detect these tumors in an early phase could improve the prognosis and survival rate. This literature review provides an overview of biomarkers, covering the different -omics fields to diagnose head and neck neoplasms in the early phase. To date, not a single biomarker, nor a panel of biomarkers for the detection of head and neck tumors has been ...

Clinical Aspects of SDHA-Related Pheochromocytoma and Paraganglioma Vrije Universiteit Brussel

Karin van der Tuin, Arjen R Mensenkamp, Carli M J Tops, Eleonora P M Corssmit, Winand N Dinjens, Anouk N A van der Horst-Schrivers, Jeroen C Jansen, Mirjam M de Jong, Henricus P M Kunst, Benno Kusters, et al.

Context: Paraganglioma (PGL) has the highest degree of heritability among human neoplasms. Current clinical understanding of germline SDHA mutation carriers is limited.

Objective: To estimate the contribution of SDHA mutations in PGL and to assess clinical manifestations and age-related penetrance.

Design: Nationwide retrospective cohort study.

Setting: Tertiary referral centers in the Netherlands (multicenter).

...

Monte Carlo proton dose calculations using a radiotherapy specific dual-energy CT scanner for tissue segmentation and range assessment Ghent University

I. P. Almeida, Lejr Schyns, A. Vaniqui, Brent van der Heyden, G. Dedes, A. F. Resch, F. Kamp, J. D. Zindler, K. Parodi, G. Landry, et al.
Proton beam ranges derived from dual-energy computed tomography (DECT) images from a dual-spiral radiotherapy (RT)-specific CT scanner were assessed using Monte Carlo (MC) dose calculations. Images from a dual-source and a twin-beam DECT scanner were also used to establish a comparison to the RT-specific scanner. Proton ranges extracted from conventional single-energy CT (SECT) were additionally performed to benchmark against literature values. ...

The phenotype of SDHB germline mutation carriers Vrije Universiteit Brussel

Nicolasine D Niemeijer, Johannes A Rijken, Karin Eijkelenkamp, Anouk N A van der Horst-Schrivers, Michiel N Kerstens, Carli M J Tops, Anouk van Berkel, Henri J L M Timmers, Henricus P M Kunst, C René Leemans, et al.

OBJECTIVE: Succinate dehydrogenase B subunit (SDHB) gene germline mutations predispose to pheochromocytomas, sympathetic paragangliomas, head and neck paragangliomas and non-paraganglionic tumors (e.g. renal cell carcinoma, gastrointestinal stromal tumor and pituitary neoplasia). The aim of this study was to determine phenotypical characteristics of a large Dutch cohort of SDHB germline mutation carriers and assess differences in clinical ...

Measurement of head and neck paragangliomas Vrije Universiteit Brussel

Berdine L Heesterman, Berit M Verbist, Andel G L van der Mey, Jean-Pierre Bayley, Eleonora P M Corssmit, Frederik Jan Hes, Jeroen C Jansen

OBJECTIVES: The aim of this study was to assess the reproducibility of different measurement methods and define the most workable technique for measuring head and neck paragangliomas, to determine the best method for evaluating tumour growth. The evaluation of tumour growth is vital for a 'wait-and-scan' policy, a management strategy that became increasingly important.

STUDY DESIGN: Method comparison study.

SETTING AND ...

Introduction: Epidemiology, Risk Factors, Pathology, and Natural History of Head and Neck Neoplasms KU Leuven

Vincent Vander Poorten
This introductory chapter sets the scene for the book by defining the complex domain in which the head and neck radiologist is expected to make his diagnosis. The epidemiology of epithelial and non-epithelial head and neck tumors is discussed representing up-to-date frequency measures. The known risk factors are subsequently reported. After that the clinical and pathological specifics of the most frequent tumors are presented, along with the ...

Diagnosis and management of parotid carcinoma with a special focus on recent advances in molecular biology KU Leuven

Vincent Vander Poorten
Recent progress in diagnosis, treatment, prognosis, and outcome of parotid cancer is reviewed. Modern imaging allows evaluation of the anatomical extent of the cancer and its relationship to the facial nerve, and the World Health Organization (WHO) Histological Classification facilitates accurate, consistent diagnosis. Surgery remains the treatment of choice with preservation of a functioning facial nerve. Resection of the facial nerve should ...