Publications

The inactivation of different spoilage organisms and surrogate pathogens in a cooked ham model product by high pressure (HP) treatment (100-700 MPa, 5-40 °C, 10 min) was investigated. A 5 log reduction could be achieved at ≥ 600 MPa at ≥ 25 °C. Subsequently, the shelf-life of packaged sliced product was studied during storage (7 °C) after treatment at 600 MPa (10 °C, 10 min) in combination with caprylic acid and Purasal®. Without HP treatment, a ...

BACKGROUND: Darbepoetin alfa is an erythropoiesis-stimulating agent (ESA), with a longer half-life than previous recombinant human erythropoietins. After its initial development for anaemia due to renal insufficiency, an extensive clinical trial program has defined its role in cancer patients. OBJECTIVE/METHODS: Review of the initial registration studies, further development and recent progress, guidelines for use in clinical practice (EORTC, ...

Nanobodies present an appealing class of potential cancer therapeutics. The current study explores the in vivo expression of these molecules through DNA-encoded delivery. We hypothesized that this approach could address the rapid clearance of Nanobodies and, through half-life modulation, increase the produced levels in circulation. We therefore evaluated pharmacokinetics and efficacy of variants of an anti-death receptor 5 Nanobody (NbDR5), ...

Stem cells have extensively been studied during the last decades as potential therapeutics in diverse disease models, including tissue regeneration and cancer. The most popular stem cell type is the mesenchymal stromal cell (MSC), which can be isolated from various foetal and adult tissues and is characterized by differentiation towards multiple functional mature cell types, including adipocytes, chondrocytes and osteocytes. Although most ...

Antibodies are widely used as versatile biological tools in cancer therapeutics. In radiopharmaceutical therapy, they have been extensively exploited as vehicles for the delivery of cytotoxic radionuclide payloads for killing tumor cells. However, their success has been impeded by high toxicity profiles due to their long circulatory half-life, which produces high radiation doses to healthy non-target tissues. This issue has prompted the ...

Large-scale vaccination strategies are currently being deployed against severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2). Whether systemic medication for skin diseases affects the efficacy of vaccination and whether temporary interruption or extension of the dosing interval is necessary is under debate. Most immunomodulating/immunosuppressive drugs only affect vaccine-induced immune responses to a limited or moderate extent, ...

Sustained parenteral drug delivery can significantly improve treatment adherence and, hence, the clinical outcome of various chronic illnesses, such as HIV and schizophrenia to name just a few. Long-acting injectable (LAI) nano-/microsuspensions constitute an attractive formulation strategy for poorly soluble drugs and have been the subject of increasing research (Chapter 1). These LAI formulations possess unique features offering important ...