Projects
HAPPY: haptic feedback the next step in smart interfacing. KU Leuven
In this project the technical enablers to make haptic feedback part of modern smart systems will be created. Haptic feedback is touch sensory feedback: smart systems can make a user feel something. Starting from preliminary research on thin film ultrasound transducers and thin film circuits combined with silicon chips, a real-time haptic feedback system will be created. An application example of this is a touch screen that lets its user feel ...
Gestalt formation in the haptic modality. KU Leuven
Visiting fellow GP03208N VENHART Martin. KU Leuven
A non-metabolic role for glutamine synthetase in regulating endothelial actin cytoskeleton dynamics during vessel sprouting? KU Leuven
Vascular endothelial cells (ECs) pervasively line the lumen of all blood vessels in the body. ECs are quiescent under physiological homeostasis but adopt one of three states in disease. EC activation includes the induction of cell adhesion molecules involved in immune cell recruitment and is associated with inflammatory diseases. EC dysfunction constitutes a state where ECs are no longer able to perform their homeostatic ...
The scaffolding actin nucleator tes: identification of domain specific interaction partners and its function in cell migration ands tumor cell invasion Ghent University
Tes, a potential tumor suppressor, controls actin cytoskeleton assembly at cellular adhesions. We will study structure-function relationships of Tes variants lacking specific domains. By combining proteomics with live cell imaging, we will determine how Tes and two identified partners regulate actin dynamics and cell migration. This will generate information on functions and mechanisms of Tes in cell migration and invasion.
Tes, a cancer-associated LIM-domain protein and novel actin nucleator with a dual function in the cytoplasm and the nucleus Ghent University
Cell migration is an important process in preserving health. The actin cytoskeleton regulates cell migration and deregulation is often associated with cancer progression. Tes, a potential tumor suppressor, possibly acts as a bi-functional sensor with cytoplasmic and nuclear activity. A structure-function relationship study of Tes and partners using proteomics, medium throughput cell migration assays and microarray experiments will be ...
Causative role of actin binding proteins in tumor progression: focus on thymosin beta isoforms Ghent University
Beta-actin mediated regulation of cell migration in embryonic development. Ghent University
Cell migration is an evolutionary conserved mechanism that underlies the development and functioning of
organisms (Tondeleir et al., 2009). Despite the differences in cell types involved, their migratory events occur
by similar molecular mechanisms that rely on a functional actin cytoskeleton. The actin system is complex and
there is reciprocal communication with the extracellular matrix and with other cells via various ...