An all human iPSC derived model to study the role of microglia in neurodegeneration KU Leuven
The hypothesis of this proposal is that microglia play both cell-autonomous and reactive roles in neurodegeneration causing dementia. Although animal models have provided important information regarding the mechanisms underlying the dementia development, they fall short in that they do not fully recapitulate the human disease. With the advent of iPSC technology combined with advanced genome engineering and (co)culture systems, we now have the ...