Projects
Development of an integrated modelling approach to study the interaction between joint contact geometry, kinematics and loading applied to the knee KU Leuven
Studying the relation between joint geometry, kinematics and loading is essential to understand how joints function, but is even more important from a clinical perspective. Deviant kinematics may, for example, adversely affect joint loading patterns, with load concentration on specific articular regions which might increase the risk of developing osteoarthritis(OA). OA is the most common agerelated joint disorder and is characterized by ...
Identification of interaction sites in the TL4 MAL-MyD88 complex and TLR4-TRAM-TRIF complex via MAPPIT and random mutagenesis Ghent University
The innate immune system is the human bodyU+2019 first line of defense against invading pathogens. This defense mechanism recognizes PAMPs through PRRs. PRRs are divided into different families, including the TLR family. The TLR family comprises 10 human members that each recognize their own set of ligands. Upon ligand detection, adaptor proteins are recruited to the TLR and the intracellular signaling pathway becomes activated. Two possible ...
Molecular analysis of the interaction between the probioticum Lactobacillus rhamnosus GG and intestinal epithelial cells KU Leuven
Probiotics are defined as “live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host”. Growing numbers of intervention trials show that certain bacterial strains ormixtures of strains, generally lactobacilli and bifidobacteria, can confer specific health benefits. Many of the interactions between probioticbacteria and the host are thought to be mediated by molecular structures, known as ...
The neural basis of value-based intentions: understanding the interaction of intentional and motivational control Ghent University
Acting according to one’s own intentions is a key aspect of human behavior. In most situations, we
have a goal we want to reach (What do I want?), and we can name reasons for wanting to reach
that goal (Why do I want it?). The proposed research will systematically investigate the interaction
of intentional (What) and motivational (Why) control processes in the brain. Previous research
largely focused on either ...
Bioinformatics for single-cell sequence and in situ RNA analytics to study cell niches and cell-cell interaction KU Leuven
single-cell RNA-seq procedures alone are insufficient to deliver comprehensive insight in organ cell atlases in health and disease. Indeed, as most of our organ functions are executed by the concerted action of individual cells in a spatially organized context, it is paramount to research single cells in their native spatial context. This is not only important to understand normal organ development and function, but also to investigate how ...
'PRIMA - towards personalized dietary recommendations based on the interaction between diet, Microbiome and Abiotic conditions in the gut - How dietary factors affect the human microbiome - Stage II Flanders Institute for Biotechnology
Control of imitation and social cognition: the interaction of motor mirroring and theory of mind Ghent University
Recent work based on ideomotor theory and Ihe discovery of the mirror neuron system has suggested that Ihe observalion
of an action is associated with Ihe aclivalion of the corresponding motor representation in the observer. In accordance with
this hypothesis it has been demonstrated that observing an action interferes with one's own actions when these are different
from those being observed. This. however. ...
Beyond Designer’s Intentions. A Semiotic Exploration of Technology Interpretation and Appropriation. KU Leuven
Although interactive technologies are always designed to serve specific purposes, it is well-known in HCI (Human-Computer Interaction) that these technologies are not always used as their designers intended. Technology use is not a matter of passive reception: through their use, users actively construct and impose new meanings on the technologies they use. Depending on the approach, this phenomenon is referred to as domestication, ...
Towards more Transparent Human-Data Interaction: Designing for Uncertainty in Digital Humanities Visualization KU Leuven
While the increased datafication of society brings about obvious benefits, it is also facing criticism for its treatment of data as an absolute, objective and raw representation of truth. To mitigate this critique, data visualisation research is developing effective ways to convey the uncertainty that underlies it.
Although data uncertainty is commonly associated with statistical dimensions such as modelling errors or forecasting ...