From genetics to the cellular phase of Alzheimer’s disease: untangling the role of lipid pathways in microglia responses to amyloid pathology KU Leuven
Microglia are critically involved in complex neurological disorders with a strong genetic component, such as Alzheimer’s disease, Parkinson's disease and Frontotemporal dementia. While mouse microglia can recapitulate aspects of human microglia physiology, they do not fully capture the human genetic aspects of disease nor reproduce all human cell states. However, primary cultures of human microglia or microglia derived from human pluripotent ...