VHL and HIF signalling in renal cell carcinogenesis University of Antwerp
Hypoxia-inducible factor (HIF) plays an important role in renal tumourigenesis. In the majority of clear cell RCC (ccRCC), the most frequent and highly vascularized RCC subtype, HIF is constitutively activated by inactivation of the von Hippel-Lindau gene. Of the HIF subunits, HIF-2 appears to be more oncogenic than HIF-1, in that HIF-2 activates pro-tumourigenic target genes. In addition, recent studies indicate that HIF-1, more than HIF-2, can ...