Electron microscopy grid University of Antwerp
In a first aspect, the present invention relates to an electron microscopy (EM) grid (100), comprising: (i) a perforated substrate (200), (ii) a support film (300) on the perforated substrate (200), the support film (300) having a thickness of 60 Å or less, preferably 20 Å or less, more preferably 10 Å or less, most preferably 3 Å or less, and (iii) linkers (400) attached on top of the support film (300), the linkers (400) comprising at least one affinity group (410) for immobilizing an analyte (500); wherein the linkers (400) form a non-random pattern on the support film (300).