MUTYH-associated polyposis carcinomas frequently lose HLA class I expression - A common event amongst DNA-repair-deficient colorectal cancers Vrije Universiteit Brussel
Human leukocyte antigen (HLA) class I expression defects frequently occur in colorectal cancers bearing mismatch repair (MMR) deficiencies and are interpreted as immune evasion mechanisms to avoid cancer cell recognition and elimination by the immune system. MMRdeficient tumours are thought to be more prone to lose HLA class I expression, due to their frequent generation of aberrant peptides which can stimulate a cytotoxic T-cell-mediated ...