HIV-1 integration as a driver of clonal expansion and HIV-1 transcription during antiretroviral therapy Ghent University
HIV-1 infection remains an incurable disease, with the latent virus persisting in the immune cells invisible to therapy and causing viral rebound within days once therapy is stopped Recent new insights show that cells that harbor HIV can divide, by a process called clonal expansion Clonal expansion of cells carrying HIV-1 is considered as being part of the main mechanisms of HIV-1 persistence, with our own data confirming its importance in ...