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Effect of HIV prevention and treatment program on HIV and HCV transmission and HIV mortality at an Indonesian narcotic prison University of Antwerp

Erni J. Nelwan, Agnes K. Indrati, Ahmad Isa, Nurlita Triani, Nisaa Nur Alam, Maria S. Herlan, Wahid Husen, Herdiman T. Pohan, Bachti Alisjahbana, Andre Meheus, et al.
Validated data regarding HIV-transmission in prisons in developing countries is scarce. We examined sexual and injecting drug use behavior and HIV and HCV transmission in an Indonesian narcotic prison during the implementation of an HIV prevention and treatment program during 2004-2007 when the Banceuy Narcotic Prison in Indonesia conducted an HIV transmission prevention program to provide 1) HIV education, 2) voluntary HIV testing and ...

Combinations of griffithsin with other carbohydrate-binding agents demonstrate superior activity against HIV type 1, HIV type 2, and selected carbohydrate-binding agent-resistant HIV type 1 strains KU Leuven

Geoffrey Férir, Dana Huskens, Kenneth E Palmer, Daniel M Boudreaux, Michael D Swanson, David M Markovitz, Jan Balzarini, Dominique Schols
Abstract Carbohydrate-binding agents (CBAs) are potential HIV microbicidal agents with a high genetic barrier to resistance. We wanted to evaluate whether two mannose-specific CBAs, recognizing multiple and often distinct glycan structures on the HIV envelope gp120, can interact synergistically against HIV-1, HIV-2, and HIV-1 strains that were selected for resistance against particular CBAs [i.e., 2G12 mAb and microvirin (MVN)]. Paired CBA/CBA ...

High rates of HIV seroconversion in pregnant women and low reported levels of HIV testing among male partners in Southern Mozambique : results from a mixed methods study Ghent University

Caroline De Schacht, Heather J Hoffman, Nédio Mabunda, Carlota Lucas, Catharina L Alons, Ana Madonela, Adolfo Vubil, Orlando C, Jr Ferreira, Nurbai Calú, Iolanda S Santos, et al.
Introduction: Prevention of acute HIV infections in pregnancy is required to achieve elimination of pediatric HIV. Identification and support for HIV negative pregnant women and their partners, particularly serodiscordant couples, are critical. A mixed method study done in Southern Mozambique estimated HIV incidence during pregnancy, associated risk factors and factors influencing partner's HIV testing.Methods: Between April 2008 and November ...

Towards more accurate HIV testing in sub-Saharan Africa: a multi-site evaluation of HIV RDTs and risk factors for false positives Institute of Tropical Medicine

Cara S Kosack, Anne-Laure Page, Greta Beelaert, Tumwesigye Benson, Aboubacar Savane, Anne Ng'ang'a, Bita Andre, Jean-Paul B. N. Zahinda, Leslie Shanks, Catharina Fransen, et al.

Introduction: Although individual HIV rapid diagnostic tests (RDTs) show good performance in evaluations conducted by WHO, reports from several African countries highlight potentially significant performance issues. Despite widespread use of RDTs for HIV diagnosis in resource-constrained settings, there has been no systematic, head-to-head evaluation of their accuracy with specimens from diverse settings across sub-Saharan Africa. We ...

Access to prevention of mother-to-child transmission of HIV along HIV services cascade through integrated active case management in 15 operational districts in Cambodia Institute of Tropical Medicine

Sovannarith Samreth, Vannak Keo, Romaing Tep, Angheng Ke, Vichea Ouk, Bora Ngauv, Sovatha Mam, Laurent Ferradini, Penh S Ly, Chhi Vun Mean, et al.

INTRODUCTION: Following the introduction of option B+ in 2013, and with the perspective of eliminating mother-to-child transmission of HIV by 2025, Cambodia has implemented an integrated active case management (IACM) approach since 2014 to improve the notification and follow-up of all HIV-infected cases including pregnant women, and to ensure access to and use of the full prevention of mother-to-child transmission (PMTCT) service package by ...

Pre-clinical evaluation of HIV replication inhibitors that target the hiv integrase-LEDGF/p75 interaction KU Leuven

Chris Pickford, Frauke Christ, Stephen Shaw, Kevin Whitby, Belete Ayele Desimmie, Caroline Smith-Burchnell, Scott Butler, Arnaud Marchand, Patrick Chaltin, Zeger Debyser, et al.
PRE-CLINICAL EVALUATION OF HIV REPLICATION INHIBITORS THAT TARGET THE HIV INTEGRASE-LEDGF/P75 INTERACTIONChris Pickford (1), Frauke Christ (2), Stephen Shaw (1), Kevin Whitby (1), Belete A. Desimmie (2), Caroline Smith-Burchnell (1), Scott Butler (1), Arnaud Marchand (2), Patrick Chaltin (2), Zeger Debyser (2), Mike Westby (1)(1) Infectious Diseases Group, Pfizer Ltd, Sandwich, Kent, UK; (2) Molecular & Cellular Medicine, Katholieke ...

Macrocyclic polyamines inhibit HIV infection by interacting with the cellular HIV co-receptors CXCR4 and CCR5 KU Leuven

Dominique Schols, Sunil Hamal, Li Cui, Dana Huskens, Stefano Aquaro, Thomas Bell
Background A number of macrocyclic polyamines and/or their metal complexes are known to have anti-HIV activity. For example, CADA compounds are triazacyclododecanes that specifically down-modulate CD4, the principal cellular receptor for HIV. Bicyclams and their metal complexes act as entry inhibitors by a different mechanism, via specific binding to the cellular co-receptor CXCR4. Manganese(II) complexes of certain penta-azacyclo-pentadecanes ...

Child desire in women and men living with HIV attending HIV outpatient clinics: evidence from a European multicentre study Institute of Tropical Medicine

Christiana Nöstlinger, F. Desjardins, J. Dec, Tom Platteau, Epco Hasker
Objectives Fertility-related decisions are challenging for women and couples living with HIV, in spite of vertical HIV transmission rates lower than 1% under effective antiretroviral treatment. This multicentre study identified factors influencing child desire of women and men living with HIV in Europe. Methods We gathered quantitative data by means of anonymous, self-administered questionnaires distributed through a network of 13 European HIV ...

Building a conceptual framework to study the effect of HIV stigma-reduction intervention strategies on HIV test uptake Institute of Tropical Medicine KU Leuven

Subash Thapa, Karin Hannes, Margaret Cargo, Anne Buvé, Arja R Aro, Catharina Mathei

A scoping review of grey and peer-reviewed literature was conducted to develop a conceptual framework to illustrate mechanisms involved in reducing HIV stigma and increasing HIV test uptake. We followed a three-step approach to exploring the literature: developing concepts, organizing and categorizing concepts, and synthesizing concepts into a framework. The framework contains four types of intervention strategies: awareness creation, ...