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An estimation of the occupational risk of HBV, HCV and HIV infection among Indonesian health-care workers University of Antwerp

Dwi Agustian, Sri Yusnita, Herman Susanto, Hadyana Sukandar, Antoon De Schryver, Andre Meheus
AIM: to estimate the occupational risk of HBV, HCV and HIV infections among Indonesian HCWs. METHODS: the model developed by WHO was used to calculate the risk. The input parameters were selected from the best available evidence in Indonesia through a literature review. RESULTS: in 2005, sharps injuries led to an estimated 1445 infections with HBV, 399 with HCV and 18 with HIV among health-care workers (HCWs) in Indonesia. The attributable ...

Screening algorithms for HBV, HCV, HIV and syphilis in an anatomical donation program Institute of Tropical Medicine

Brecht Valcke, Koen Vercauteren, Elizaveta Padalko, Chris Verhofstede, Katharina D'Herde, Wouter Willaert

BACKGROUND: Users of anatomical donors are at risk of exposure to bloodborne pathogens. This study evaluated screening algorithms for hepatitis B and C virus, human immunodeficiency virus and Treponema pallidum during donor allocation and assessed the impact of postmortem time on hemolysis and how hemolysis affects test results and donor discard rate.

METHODS: From 2011 to 2018, demographic data of anatomical donors, time of postmortem ...

Effect of HIV prevention and treatment program on HIV and HCV transmission and HIV mortality at an Indonesian narcotic prison University of Antwerp

Erni J. Nelwan, Agnes K. Indrati, Ahmad Isa, Nurlita Triani, Nisaa Nur Alam, Maria S. Herlan, Wahid Husen, Herdiman T. Pohan, Bachti Alisjahbana, Andre Meheus, et al.
Validated data regarding HIV-transmission in prisons in developing countries is scarce. We examined sexual and injecting drug use behavior and HIV and HCV transmission in an Indonesian narcotic prison during the implementation of an HIV prevention and treatment program during 2004-2007 when the Banceuy Narcotic Prison in Indonesia conducted an HIV transmission prevention program to provide 1) HIV education, 2) voluntary HIV testing and ...

Association of HIV infection with anal and penile low-risk human papillomavirus infections among men who have sex with men in Amsterdam: the HIV & HPV in MSM study Institute of Tropical Medicine

Camiel A H Welling, Sofie H Mooij, Marianne van der Sande, Martijn S van Rooijen, Wilma F Vermeulen-Oost, Audrey J. King, Arne van Eeden, Danielle A. M. Heideman, Ineke G Stolte, Maarten F. Schim van der Loeff, et al.

BACKGROUND: This study among men who have sex with men (MSM) aimed to (1) assess prevalence of anogenital low-risk human papillomavirus (lrHPV) infections, (2) evaluate associations with HIV infection, and (3) investigate lrHPV concordance.

METHODS: In 2010 to 2011, MSM 18 years or older were recruited in Amsterdam, the Netherlands, and provided anal and penile self-swabs (HIV & HPV in MSM study). Using the HPV SPF10-PCR/DEIA/LiPA25 ...

Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users Vrije Universiteit Brussel KU Leuven

Simona Paraschiv, Leontina Banica, Ionelia Nicolae, Iulia Niculescu, Adrian Abagiu, Raluca Jipa, Andrea-Clemencia Pineda-Peña, Marta Pingarilho, Emil Neaga, Kristof Theys, et al.

Co-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to characterize and compare transmission dynamics of the two viruses. Three large HIV ...

Joint Modeling of HCV and HIV Infections among Injecting Drug Users in Italy Using Repeated Cross-Sectional Prevalence Data Hasselt University University of Antwerp

Emanuele DEL FAVA, Adetayo KASIM, Usman Muhammed, Ziv SHKEDY, Niel HENS, Marc AERTS, Kaatje BOLLAERTS, Gianpaolo Scalia Tomba, Peter Vickerman, Andrew J. Sutton, et al.
During their injecting career, injecting drug users (IDUs) are exposed to some infections, like hepatitis C virus (HCV) infection and human immunodeficiency virus (HIV) infection, due to their injecting behavioral risk factors, such as sharing syringes or other paraphernalia containing infected blood, or sexual behavior risk factors. If we consider that these IDUs might belong to a social network of people where these behavioral risk factors are ...

Exploration of the in vitro antiviral activity of a series of new pyrimidine analogues on the replication of HIV and HCV. KU Leuven

Pieter Leyssen, Christophe Pannecouque
BACKGROUND: In continuation of our search for new anti-HIV and anti-HCV agents, the suggestion, synthesis and structure elucidation of a new series of 2,6-diamino-4-alkylthio- or (2-benzylhydrazinyl)-5-p-chlorophenylazopyrimidines), 2,6-diamino-4-(2-benzylhydrazinyl)-5-(aryl-[1,1'-biphenyl]-4-yl)pyrimidines, 2,6-diamino-4-(aryl)-5-(aryl[1,1'-biphenyl]-4-yl) pyrimidines), 6-(aryl)-1,3-dimethyl-5-nitro pyrimidine-2,4-dione and ...

Joint modeling of HCV and HIV co-infection among injecting drug users in Italy and Spain using individual cross-sectional data University of Antwerp

Emanuele Fava, Del, Ziv Shkedy, Niel Hens, Marc Aerts, Barbara Suligoi, Laura Camoni, Fernando Vallejo, Lucas Wiessing, Mirjam Kretzschmar
The aim of the analysis presented in this paper is to study co-infection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) in injecting drug users (IDUs) using a joint modeling approach that makes use of multivariate statistical methods for current status data. Using marginal models, we estimate association measures between HCV and HIV infections at individual level, i.e., odds ratios and correlation coefficients, and we ...

Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication KU Leuven

Johan Neyts, Jan Balzarini
9-[2-(Thiophosphonomethoxy)ethyl]adenine 3 and (R)-9-[2-(Thiophosphonomethoxy)propyl]adenine 4 were synthesized as the first thiophosphonate nucleosides bearing a sulfur atom at the α-position of the acyclic nucleoside phosphonates PMEA and PMPA. Thiophosphonates S-PMEA 3 and S-PMPA 4 were evaluated for in vitro activity against HIV-1 (subtypes A to G), HIV-2 and HBV-infected cells, and found to exhibit potent antiretroviral activity. We showed ...