Research on the mechanism of action of a new class antivirals, the LEDGINs, with a potential application for the functional cure of HIV infection KU Leuven
HIV-1 persists lifelong in memory cells of the immune system as latent provirus that rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an HIV cure. In order to find such cure further research on the determinants of HIV latency is essential. During my PhD, I investigated the role of integration sites in HIV-1 pathogenesis.
HIV integration is catalyzed by the viral integrase (IN) enzyme that ...